RESULTS. Predominant drug sensitivities include the highly potent but expected pan-cytotoxic effects of compounds that target microtubules, the proteasome, topoisomerases, DNA/RNA synthesis and histone deacetylases. Beyond these, approximately 50 compounds have been selected for further studies including ...
Paclitaxel (PTX) is a cytotoxic drug extracted from Taxus and enables interaction with β-microtubule proteins, thereby causing the aggregation of microtubules causing cell cycle cessation in the G2/M phase and inducing apoptosis. PTX has shown superior therapeutic effects on cancers including breast,...
This review mainly discusses the research progress of RNA modifications in the field of cancer and drug resistance and targeting of m6A regulators by small molecule modulators, providing reference for future study and development of combination therapy to reverse cancer drug resistance....
drugs were chosen to have a high drug distance as well as a high sensitivity in GBM cell lines (Supplementary Figs.1dand3a(showing sensitivity and distance, respectively)). We tested a total of 30 different combinations (Supplementary Data1) onto 9 ...
Tau, a microtubule-associated protein (MAP) functions in maintaining the assembly as well as disassembly of the microtubules [183]. An aberration in tau phosphorylation disrupting its normal physiology is known to be the cause of neurodegenerative disorders such as AD. Conditions such as ...
targeting them has proven to be a promising therapeutic approach to overcome resistance. Various reports demonstrated that the expression of Notch1 plays a central role in increasing trastuzumab resistance in BT474, SK-BR3, and MCF-7 cells, and its inhibition (genetic or pharmacological) sensitizes...
(Supplementary Fig.14a). Secondly, this signature SBS30L/7bL/11L associates with sensitivity to the vinca alkaloids vinblastine, vincristine, and vinorelbine that interfere with assembly of microtubules and forming of the mitotic spindle (Supplementary Fig.14b). These associations were observed across...
Targeting programmed cell death is a major approach of antitumor drug development. Deregulation of programmed cell death (PCD) contributes to resistance to a variety of cancer therapeutics. Yes-associated protein (YAP) and its paralog TAZ, the main downstream effectors of the Hippo pathway, are ...
Therefore, targeting autophagy has drawn considerable attention as a therapeutic approach for the treatment of AD. However, developing new therapeutics is time-consuming and requires huge investments. One of the strategies currently under consideration for many diseases is “drug repositioning” or “...
Thus, it is summarized from previously conducted researches that diseases can be managed by targeting specific components of ECM which are involved in the pathophysiology of diseases. Moreover, the drug delivery focused on targeting the ECM components also has the potential for the discovery of ...