Prediction of drug-target interactions (DTI) plays a vital role in drug development in various areas, such as virtual screening, drug repurposing and identification of potential drug side effects. Despite extensive efforts have been invested in perfectin
S. Fibroblast growth factor 21 as an emerging therapeutic target for type 2 diabetes mellitus. Med. Res. Rev. 36, 672–704 (2016). CAS PubMed Google Scholar Sanyal, A. et al. BMS-986036 (PEGylated FGF21) in patients with non-alcoholic steatohepatitis: a phase 2 study. J. Hepatol. ...
The examination of how various drugs interact with the body and how a medication needs to act on the body to have a therapeutic impact is known as drug discovery. Drug discovery strategy constitutes from different approaches as physiology-based and target based. This strategy is based on informat...
Recent studies have indicated that the microbiota is a vital drug target in many disease treatments. Many therapeutics have great effects on altering the composition of the microbiota. As indicated in Fig. 2A, changes in microbiota in the gastrointestinal tract may influence the metabolism of co-ad...
Target Product Profile (TPP) - defined as a planning tool for promising therapeutic candidates - has a major role in de novo drug discovery. Basically, TPP takes into account factors, such as compounds’ clinical efficacy, delivery mode, safety and tolerability, contraindications, dosage form, sta...
The shaded areas are the simplified systems. Based on the simplification rules the virtual inhibitors on the simplified systems in this example target on the reaction B-P+C→C-P (or it also could be seen as target on component B-P) and component C. Full size image...
Therefore, it enables the reduction of off-target toxicities and enhances the therapeutic index of the drug. Hepatocellular carcinoma (HCC) is a solid tumor that shows high heterogeneity of molecular phenotypes and is considered the second most common cause of cancer-related death. Studies show ...
intervention are mainly passive targeting, so active targeting with a stimulus response can be considered. For example, the delivery vector of 5-aminolevulinic acid adopts a photothermal response. It allows the drug to be released at the target site to reduce the impact on other sites to achieve...
Color in the dots indicates expression level the drug target ERBB2 in PDXs. The blue line is the linear regression line Full size image Next, we investigated whether a predictor of drug response trained on the cell lines would correctly predict sensitivity in PDX models. To this end, we ...
We also found 10 drugs that could be potential multi-target drugs, such as fluorouracil that targets four genes (HMMR, EXO1, TOP2A, and MYB-TF). Additionally, each of the four anthracycline antitumor antiobiotics (doxorubicin, daunorubicin, idarubicin, and epirubicin) can target two genes....