19,20, there remain two key challenges that could enhance the clinical relevance of repurposing predictions. First, these approaches assume that we want to make therapeutic predictions for diseases that already have existing drugs. Although this is the case for some diseases9, a long ...
h were significantly lower for remdesivir (32.2% [±2.7] and 12.4% [±2.1], p < 0.001), nafamostat (21.4% [±5.0] and 0.0% [±0.0], p = 0.018). Reduced concentrations of COVID-19 drug treatments in ECMO circuits is a clinical concern. Remdesivir and nafamostat may need dose ...
The SARS-CoV-2 3CL protease is a critical drug target for small molecule COVID-19 therapy, given its likely druggability and essentiality in the viral maturation and replication cycle. Based on the conservation of 3CL protease substrate binding pockets across coronaviruses and using screening, we...
In this episode of the Drug Solutions podcast, Jill Murphy, former editor, speaks with Bourji Mourad, partnership director at ThermoSafe, about the supply chain in the pharmaceutical industry, specifically related to packaging, pharma air freight, and the pressure on suppliers with post-COVID-19 ...
In this section, we first describe our data sources and the preprocessing steps that were taken to construct a literature knowledge graph from these data sources. Next, we discuss the knowledge graph completion methods that we used to predict candidate drugs for COVID-19 as well as the discover...
“Covid-19 continues to mutate, causing pandemic resurgence across the globe. Vaccines and drug treatments remain to be powerful weapons for humans to combat viruses,” Fosun Pharmaceutical’s CEO Wen Deyong said. “Azvudine tablet is the first Covid-19 drug taken by mouth developed by a Chi...
The dosage used for COVID-19 is the same as HIV-1 treatment: 400/100 mg, twice daily for 7–14 days. Pharmacokinetic interactions Lopinavir and ritonavir are strong inhibitors of cytochrome P450 isoform CYP3A, thus increasing the concentration of numerous CYP-substrate drugs. They are also ...
Nearly 6 million Americans have takenPaxlovidfor free, courtesy of the federal government. The Pfizer pill has helped prevent many people infected withCOVID-19frombeing hospitalizedor dying, and it may evenreduce the riskof developinglong COVID. But the government plans to stop footing the bill...
Enhancement of material attributes of poorly compressible metformin hydrochloride through coprocessing with hydroxypropyl cellulose (HPC-L) using coprecipitation (CPT) Coprocessing involves integration of multiple substances to improve the physical, chemical, mechanical, and biopharmaceutical properties of a mat...
et al. Injection fears and COVID-19 vaccine hesitancy. Psychol. Med. https://doi.org/10.1017/S0033291721002609 (2021). Article PubMed PubMed Central Google Scholar Marien, A.-G. et al. Parental acceptance of an intranasal vaccine: example of influenza vaccine. Arch. Pédiatrie 26, 71–...