The results indicate a drug drug interaction between N-acetyl-p-benzoquinone-imine (NAPQI) derived from the anodic oxidation of acetaminophen and beta-lactam antibiotics. Also the cyclic voltammetric data were
et al. Comparative pharmacokinetics between a microdose and therapeutic dose for clarithromycin, sumatriptan, propafenone, paracetamol (acetaminophen), and phenobarbital in human volunteers. Eur. J. Pharm. Sci. 43, 141–150 (2011). CAS PubMed Google Scholar Maeda, K. et al. Identification of ...
The top 15 drugs or drug classifications that are involved in toxicity include acetaminophen, alcohol, benzodiazepines, anticoagulants, antidepressants, antihypertensives, bromocriptine (an anti-Parkinson's drug), clarithromycin (an antibiotic), clozapine (an antipsychotic), cocaine, colchicine (an anti...
This study shows the power of the large accumulated data sets in the BXD mouse genetic reference population to connect genotype with phenotypes, using a range of strategies including PheWAS, transcriptome-wide association studies, proteome-wide association studies and mediation analysis. CAS PubMed ...
Fig. 2.Temporal variations in mean plasma half-life (min) and mean plasma free 11-hydroxycorticoids (μg/100 ml) in normal males after a single oral dose of either acetaminophen or phenacetin. Data are graphed as percent of control, using the mean 6:00 a.m. value as control. Mean ±...
The drugs tested were acetaminophen, fialuridine, tenofovir, inarigivir soproxil or tenofovir, and inarigivir soproxil. For all the different iPSC-derived organoids, acetaminophen increased ALT levels, while fialuridine led to an increase of both ALT and AST; albumin levels were instead reduced ...
Due to differ- ences in nomenclature, some ratios were not calculated (e.g., paracetamol is translated to acetaminophen and acetylsali- cylic acid to aspirin by RxNorm). For some drugs, the added value of DiAna translation for case retrieval was extremely high; for example, rimegepant (...
Paracetamol (acetaminophen) is one of the most frequently used analgesics, and is the most commonly used substance in self-poisoning in the US and UK. Paracetamol toxicity is manifested primarily in the liver. Treatment withN-acetylcysteine (NAC), if started within 10 hours from ingestion, can ...
Role of bile acids in liver injury and regeneration following acetaminophen overdose. Am J Pathol. 2013;183(5):1518–26. Article CAS PubMed PubMed Central Google Scholar Scoazec JY. Drug-induced bile duct injury: new agents, new mechanisms. Curr Opin Gastroenterol. 2022;38(2):83–8. ...
The animal study revealed that there was no tumor regrowth, six weeks post-treatment, when the LHRH targeted drugs (LHRH-PTX and LHRH-PGS) were used for the treatment. The possible cytotoxic effects of the released drugs on the liver, kidney, and lung are assessed using quantitative ...