After estimating the individual kinetic parameters by the Bayesian method, the program predicts the dosage regimen that will elicit the desired peak and trough plasma levels at steady state. For comparison purposes, the least-squares estimates for clearance and volume of distribution are calculated, ...
[20] Brenner MC, Murray CJ, Klinman JP (1989) Rapid Freeze and Chemical-Quench Studies of Dopamine-Beta-Monooxygenase: Comparison of Pre-Steady-State and Steady-State Parameters. Biochemistry 28: 4656–4664. [21] Blackburn NJ, Hasnain SS, Pettingill TM, Strange RW (1991) Copper K-Extended...
(IC50), literature search metrics from other 3D models (IC50), and HuP3D metrics, as well as effective concentrations in patients from phase I or II studies that examined the pharmacokinetics of the tested chemotherapies (steady state concentration, Css) and examples of low positive and high ...
murine myeloma cells in culture. To determine the mechanistic basis of this observation, we performed metabolomic analyses of resistant cells and resistant drug-induced cells in a steady state, or incubation with stable isotope-labeled tracers, namely,13C15N-amino acids. Taken together, these results...
Without stirring, diclofenac permeated through the dialysis membrane very slowly and there was a lag time of several minutes before steady-state permeation was reached (Figure 6). Furthermore, the permeated amount was approximately 20% lower during the release phase and reached a plateau after 6 ...