Dose response for starting and stopping HIV preexposure prophylaxis for men who have sex with men This study estimated the number of daily tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) doses required to achieve and maintain (after discontinuatio... SM Seifert,DV Glidden,AL Meditz,... -...
he development of a new drug requires strict adherence to the Code of Federal Regulations, starting with the application for study of the compound in human subjects. Prior to a drug's entry into the clinic, pharmaceutical companies (hereafter referred to as sponsors) must test the drug candidate...
While some molecules may serve simply as starting scaffolds, with patents filed on compounds derived from them or protected through method-of-use patents. Show moreView chapterExplore book Emerging antiviral therapeutics for human adenovirus infection: Recent developments and novel strategies Mackenzie J....
In our experiments, we found that puromycin was indeed unstable over time, as we observed that after collecting exclusively male flies from the vials with 0.4 mg/ml of puromycin for eight straight days at +25 °C, a few female flies would emerge starting at day 9 (Supplementary Data...
The advantage of starting with a dry, drug-impregnated polymer to obtain the desirable zero order release rate while the hydrogel absorbs water is illustrated. Drugs have been classified into five groups showing different release profiles. The effects of design and loading on the release profile, ...
Half-life (t1/2) is defined as the amount of time required for the drug concentration measured in plasma (or other biological matrices) to be reduced to exactly half of its starting concentration or amount. After IV dosing, the drug concentrations in plasma decline due to both elimination and...
This article presents the views of a diverse group of international experts on the ‘grand challenges’ in small-molecule drug discovery with AI and the approaches to address them.This is a preview of subscription content, access via your institution ...
Medical Therapy for the Prevention of Relapsing Nasal Polyposis: A Pilot Study on the Use of Furosemide by Inhalation Starting from the observation that edema, vessel dilatation, and inflammatory cells infiltration are the histopathological elements characteristic of nasal... D Passàli,L Bellussi,M ...
Ann J. Sjoerdsma, ,Starting with serotonin: how a high-rolling father of drug discovery repeatedly beat the odds (2008) Improbable Books,Silver Spring, MD x + 617 pp., hardback, ISBN: 13:978-0-615-16558-5 (US$27.50).doi:10.1016/j.trstmh.2008.10.010Geoffrey...
(which started with 1287 features in the Poore et al. data) and 5% of worst remaining features per recursive step until 1300 features were reached followed by the one worst feature per recursive step for gene expression (starting with 60,483 features in GENCODE v22) and combined data type ...