The development of nanocarriers for targeted protein delivery requires methods for high-throughput screening in vitro and in vivo. Here authors develop a DNA-barcoded method to identify nanocarriers with different biodistributions, and demonstrate delivery of catalase to the kidneys of female mice, succ...
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A designated employer representative (DER) is someone on your team who helps you navigate through drug screening and drug-related matters in the workplace, like how to determine when you have reasonable suspicion for performing drug testing. We will train your DER, so your business is equipped ...
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The search for small molecules that bind to the target is begun by screening libraries of potential drug compounds. This may be done by using the screening assay (a “wet screen”). In addition, if the structure of the target is available, a virtual screen may be performed of candidate d...
Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, and Guangdong-Hong Kong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceut...
Fragment screening of GPCRs using biophysical methods: identification of ligands of the adenosine A2A receptor with novel biological activity. ACS Chem. Biol. 7, 2064–2073 (2012). Article CAS PubMed Google Scholar Igonet, S. et al. Enabling STD-NMR fragment screening using stabilized native ...
Biological and phytochemical screening of plants. J Pharmaceutical Sci. 1966; 55:225-276. 15. Eweis M, Elkholy SS, Elsabee MZ. Antifungal efficacy of chitosan and its thiourea derivatives upon the growth of some sugar-beet pathogens. Int J Biol Macromol. 2006; 38:1-8. 16. K n u d ...
Screening is routine use, considered mandatory by all major regulatory bodies, and shown to be cost-effective (Hughes et al. Citation2004). The 3D structure of the HLA-B*57:01-abacavir-peptide complex has been resolved via X-ray crystallography, revealing an altered peptide-binding repertoire ...