Initially, the sole source of taxol was the bark of the Pacific yew, native to the old-growth forests along the northwest coast of the United States and inBritish Columbia. This led to considerable public controversy. Environmental groups feared that harvesting of the yew would endanger its surv...
Drug screening data from massive bulk gene expression databases can be analyzed to determine the optimal clinical application of cancer drugs. The growing amount of single-cell RNA sequencing (scRNA-seq) data also provides insights into improving therape
Drug nanoaggregates are particles that can deleteriously cause false positive results during drug screening efforts, but alternatively, they may be used to improve pharmacokinetics when developed for drug delivery purposes. The structural features of molecules that drive nanoaggregate formation remain elusi...
fSummary of relative gene expression for individual lineages in each gene module from heatmap panelsc,dand list of Hallmark enriched pathways related to each gene module based on enrichment analysis gprofilers statistical tests withP-adj < 0.05. Bar size denotes the number of genes in each ...
Columbia-Suicide Severity Rating Scale DBP: Diastolic blood pressure DSM-IV: Diagnostic and Statistical Manual of Mental Disorders FBG: Fasting blood glucose FEDN: First-episode and drug naïve HAMA: Hamilton Anxiety Scale HAMD: Hamilton Depression Scale HDL-C: High-density lipoprotein cho...
(20); Hasan Garan, Columbia University Medical Center, New York, New York (20); Eric Michael Crespo, Hartford Hospital, Hartford, Connecticut (19); Peter Cheung, Scott and White Memorial Hospital, Temple, Texas (previously David Fitzgerald) (18); Gerian Groenefeld, Asklepios Klinik Barmbek, ...
British Columbia, Canada, is experiencing a public health emergency related to opioid overdoses driven by consumption of street drugs contaminated with illicitly manufactured fentanyl. This cross-sectional study evaluates a drug checking intervention for the clients of a supervised injection facility (SIF...
The solutions from outer reservoir (free drug) were than collected and transferred to an autosampler vial for HPLC analysis (Prominence LC2030, Shimadzu, Columbia, MD) with photodiode-array detection (PDA) system. Separation was achieved with a Luna® 5 µm C18(2) 100 Å LC column...
Department of Pharmacology, Physiology & Neuroscience, University of South Carolina School of Medicine, Columbia, SC, USA Michy P. Kelly Corresponding author Correspondence to Michy P. Kelly. Ethics declarations Competing interests G.S.B. is co-founder and director of Portage Glasgow Limited. The ...
NIXON PEABODY, LLP (WASHINGTON, DISTRICT OF COLUMBIA, US) Claims: What is claimed is: 1.A monolithic drug delivery dosage form comprising a salted-out and crosslinked polymer having a pharmaceutically active agent disposed therewith, wherein the polymer is poly-lactic co-glycolic acid and is cro...