While it is difficult to tamper with a specimen, attempts have been made to alter samples, most often urine. Abnormalities in the urine screen may indicate that results may be a false negative or that there was deliberate adulteration of the sample....
Results Design principle and workflow IDACombo relies on the principle of IDA, predicting that the efficacy of a drug combination in a given cell line or patient will be equal to the effect of the single best drug in that combination (Fig. 1a). Importantly, IDACombo predictions are concentrat...
et al. High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing. Proc. Natl Acad. Sci. USA 115, E9944–E9952 (2018). Article CAS PubMed PubMed Central Google Scholar Sago, C. D. et al. Nanoparticles that deliver RNA to bone ...
it is known that too much sample in solution causes false-positive results when that sample contains crystal meth or MDMA [54]. In the case of benzodiazepine test strips, etizolam, a benzodiazepine-related compound, has been shown to interact poorly [16,...
Ben-David U, Gan QF, Golan-Lev T, Arora P, Yanuka O, Oren YS, Leikin-Frenkel A, Graf M, Garippa R, Boehringer M, Gromo G, Benvenisty N (2013) Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen. Cell Stem ...
Model 1 was a univariate model of NT-proBNP; model 2 was a multi-factorial model of age, gender and NT-proBNP; model 3 used stepwise regression to screen for risk factors including body mass index (BMI), hypertension, diabetes, current smoking, previous MI, previous PCI, previous CABG, ...
An earlier solid form screen would also have prevented the repeat of major studies late in development, as seen when atorvastatin Form I was found. Screening studies do not guarantee that all forms have been found, but they have significantly reduced the risk for most programs. The patents ...
One possible explanation for the distinct results in the murine model and human trials is that the former represents the early stage of chronic Chagas disease in which the response of the drugs can be overestimated. Besides that, it has been suggested that in the late chronic stage of the ...
Results are presented as mean ± SEM. Statistical analyses were performed in GraphPad Prism using the one-sample t test for two groups and one-way ANOVA followed by Tukey analysis for two or more groups. p < 0.05 was considered significant. Statistical analysis of the small molecule screen is...
Such applications include identifying disease-associated screenable phenotypes, understanding disease mechanisms and predicting a drug’s activity, toxicity or mechanism of action. Several of these applications have been recently validated and have moved into production mode within academia and the ...