Doss M, Becker U, Peter HJ, Kaffarnik H. Drug safety in porphyria: risks of valproate and metoclopramide. Lancet. 1981;2(8237):91.Doss M, Becker U, Peter HJ, Kaffarnik H (1981) Drug safety in porphyria: Risks of valproate and metoclopramide. Lancet 2: 91 View Article...
NLA task force on statin safety–2014 update. J Clin Lipidol. 2014;8(3 Suppl):S1-4. https://doi.org/10.1016/j.jacl.2014.03.003. Article PubMed Google Scholar Ortinski P, Meador KJ. Cognitive side effects of antiepileptic drugs. Epilepsy Behav. 2004;5(Suppl 1):S60–5. https://...
rifampicin (rifampin) and several anticonvulsant drugs; valproic acid (sodium valproate) does not have this effect. Antibiotics may interfere with enterohepatic recirculation of ethinylestradiol and reduce plasma levels of active hormone. This is probably only of significance in a subgroup...
DILI is a safety concern that leads to the termination of clinical drug development programs and is the primary reason for drug withdrawal post-marketing [4,5]. DILI may remain undetected prior to drug approval, and preclinical safety data is insufficient for early prediction in humans [6]. Fu...
CAPLYTA® (lumateperone) is indicated in adults for the treatment of schizophrenia and for the treatment of depressive episodes associated with bipolar I or II disorder (bipolar depression) as monotherapy and as adjunctive...
The safety profile in this study is consistent with prior Lennox-Gastaut and Dravet syndrome studies, with confirmation of cannabidiol-associated risks of transaminase level elevations (especially in the presence of valproate) and somnolence and sedation (especially in the presence of clobazam). Back...
As for the other axial position, it was functionalized with different molecules, all of which were shown to have a synergistic effect in combination with cisplatin: phenylbutyrate (PhB) and valproate (Val) (two histone deacetylase inhibitors), dichloroacetate (DCA) (a pyruvate dehydrogenase kinase ...
Stimulation of ACTH/cortisol by intravenously infused substance P in normal men: inhibition by sodium valproate. Neuroendocrinology 56, 459–463 (1992). Article CAS PubMed Google Scholar Kramer, M. S. et al. Distinct mechanism for antidepressant activity by blockade of central substance P ...
Epilepsy is one of the most common neurological disorders. Even though existing antiepileptic drugs can render 80% of newly diagnosed patients seizure free, a significant number of patients have chronic intractable epilepsy causing disability with considerable socioeconomic implications. There is, therefore...
Augmentation with thyroid hormones appears to be well tolerated and effective. Case reports and open studies indicate that augmentation with buspirone and the psychostimulants, carbamazepine and valproic acid (valproate sodium) is effective and results in minimal adverse effects. However, there is no ...