This is the protocol for a review and there is noThe objectives are as follows: To evaluate the effectiveness and safety of topiramate for treating drug dependence when compared to placebo, other pharmacotherapy, other psychosocial interventions or no intervention....
NLA task force on statin safety–2014 update. J Clin Lipidol. 2014;8(3 Suppl):S1-4. https://doi.org/10.1016/j.jacl.2014.03.003. Article PubMed Google Scholar Ortinski P, Meador KJ. Cognitive side effects of antiepileptic drugs. Epilepsy Behav. 2004;5(Suppl 1):S60–5. https://...
lamotrigine, gabapentin, oxcarbazepine, felbamate, tiagabine, eterobarb, zonisamide, remacemide, stiripentol, topiramate and levetiracetam (ucb-L059). Of the 12 drugs, vigabatrin, lamotrigine and gabapentin have recently been marketed in the UK. Five of these...
However, the treatment of obesity itself has proven largely resistant to therapy, with anti-obesity medications (AOMs) often delivering insufficient efficacy and dubious safety. Here, we provide an overview of the history of AOM development, focusing on lessons learned and ongoing obstacles. Recent ...
In addition to enhancing efficacy and safety, combining treatments with complementary mechanisms may also lead to synergistic effects on patient outcomes, for instance through increased medication adherence. This is supported by a recent meta-analysis which identified drug-related factors including side ...
Molecular pharmacology of topiramate: managing seizures and preventing migraine. Headache 45 (Suppl. 1), S48–S56 (2005). Article PubMed Google Scholar Gurvich, N. & Klein, P. S. Lithium and valproic acid: parallels and contrasts in diverse signaling contexts. Pharmacol. Ther. 96, 45–66...
Objective Infantile Spasms (IS) is one of the catastrophic epileptic syndromes of infancy.The purpose of this study was to evaluate clinical efficacy and safety oftopiramate (TPM) as the first -line drug in the treatment of infantile spasms. Materials and Methods In a quasi- experimental study,...
In addition, the update addresses the role of the time-to-event design in epilepsy clinical trials; this novel trial design is considered acceptable as an adjunct to other approaches, but it is not recommended as the sole design due to its limited ability to assess efficacy and safety over ...
Safety and efficacy of intranasal ketamine for the treatment of breakthrough pain in patients with chronic pain: a randomized, double-blind, placebo-controlled, crossover study. Pain. 2004;108(1–2):17–27. CAS PubMed Google Scholar Suzumura A, Ito A, Yoshikawa M, Sawada M. Ibudilast ...
even if they do not have the same chemical structure or direct target. The idea is that discovering another medicine with a similar genetic mechanism of action might lead to a new therapeutic with greater efficacy or safety. Many researchers created an automated technique that uses similarity in ...