Intrinsic Drug Resistance Drug resistance that is present from the onset of therapy whereby a subpopulation of tumor cells are inherently resistant to the treatment regimen. Acquired Drug Resistance An initial response to treatment followed by subsequent progression of disease. This occurs when a ...
transporter, permeability glycoprotein (P-gp)30. There are a large number of studies showing that P-gp can be transferred from drug-resistant tumor cells to sensitive cells through exosomes, leading to acquired drug resistance in vitro and in vivo31,32,33. Similarly, Lv et al.24demonstrated t...
"This study shows that an agent that targets the degradation of both HER2 and EGFR is highly effective in overcoming drug resistance in this disease," Zhang said. "The findings provide new insights and innovations for advancing treatment of drug-resistant HER2-positive breast cancer that remains a...
have found a method for long-term control of drug-resistant breast cancer growth in preclinical models by switching between estrogen and anti-estrogen therapies. The strategy is now in human clinical trials at Dartmouth's and Dartmouth-Hitchcock's Norris Cotton Cancer Center. Credit: Mark Washburn...
cytotoxic effects. This combination is also recommended for early treatment as well as trastuzumab-resistant breast cancers [44]. Margetuximab is also used in combination with chemotherapeutic agents for the management of HER2+metastatic breast cancer. It enhances NK cells activity due to its high ...
www.nature.com/scientificreports OPEN Discovery of monocarbonyl curcumin-BTP hybrids as STAT3 inhibitors for drug-sensitive and received: 31 October 2016 accepted: 15 March 2017 Published: 11 April 2017 drug-resistant breast cancer therapy Wenda Zhang, Jianpeng Guo, Shanshan Li, Ting Ma,...
Herein, we conducted gene expression analyses of HER2 kinase inhibitor-resistant cell lines as compared to their drug-sensitive counterparts. These data demonstrate the induction of epithelial–mesenchymal transition (EMT), which included enhanced expression of fibroblast growth factor receptor 1 (FGFR1) ...
promoting breast cancer progression. Our findings indicate the key functional role of exosomal EphA2 in the transmission of aggressive phenotype between cancer cells that do not rely on direct cell-cell contact. Our study also suggests that the increase of EphA2 in drug-resistant cell-derived ...
Cancer Drug Resistance is a peer-reviewed journal led by Editor-in-Chief Godefridus J. (Frits) Peters, covering drug resistance research on breast cancer, lymphatic cancer, hematological malignancies, thyroid cancer, lung cancer, stomach cancer, esophage
Our findings suggest that a CAN diet inhibits tumor growth and sensitizes drug-resistant breast cancer cells to treatment, due in part to alteration of gene expression. Overall, these novel findings advance the understanding of the role of dietary fat in breast cancer treatment, and future studies...