Deaths from drug-resistant infections are set to skyrocket by 2050, according to the UN 2023 report‘Bracing for Superbugs: Strengthening environmental action in the One Health response to antimicrobial resistance.’ Unless drastic action is taken to tackle the problem, it could also lead to a GDP...
Drug resistanceis well-defined as a serious problem in our living world. To survive, microbes develop defense strategies against antimicrobial drugs. Drugs exhibit less or no effective results against microbes after the emergence of resistance because they are unable to cross the microbial membrane, i...
ChelseaWareMS, PA-C, ...Eric C.NemecPharmD, MEd, BCPS, inPhysician Assistant Clinics, 2023 Drug-Resistant Tuberculosis Drug-resistant TB is becoming more common globally, with approximately half a million of those developing TB havingRIFresistance in 2019. Resistance can develop at the onset ...
but not SbIII-, MF- or AMB-resistant mutants, became rapidly cross-resistant to methotrexate, a model drug also not producing ROS. Our results therefore link the mode of killing of drugs to tolerance to cell death and to a facilitated emergence of multidrug resistance. These findings may have...
In addition, when used to cleave target sequences, the system can act on identical or homologous DNA sequences of the host that can lead to cell death or transformation [52,141]. Its use has also been linked to the development of antimicrobial resistance [142]. Figure 4. CRISPR/Cas9 ...
drugalone. Protease inhibitors also slow the emergence of resistant virus. The principal adverse effects ofproteaseinhibitors are nausea and diarrhea. Long-term use can bring on a syndrome known as lipodystrophy (wasting ofperipheralfat, accumulation of central fat, hyperlipidemia, andinsulinresistance)...
This drug-tolerant state has been hypothesized to be part of an initial strategy towards eventual acquisition of bona fide drug-resistance mechanisms. However, the diversity of drug-resistance mechanisms that can expand from a persister bottleneck is unknown. Here we compare persister-derived, ...
Cancer Drug Resistance is a peer-reviewed journal led by Editor-in-Chief Godefridus J. (Frits) Peters, covering drug resistance research on breast cancer, lymphatic cancer, hematological malignancies, thyroid cancer, lung cancer, stomach cancer, esophage
The present review envisages the role of nanovaccines to combat the global challenges of antimicrobial resistance. Nanovaccines are a novel formulation comprised of nanomaterials coupled with an immunogenic component to elicit the immune response and provide protection against the desired infectious disease...
AZD7545 both prevented PDH phosphorylation in H460parand H460rescells, but activated AMPK, induced cell death and inhibited clonogenic growth only in H460rescells (Supplementary Fig.4a, b), thereby validating PDH kinases as a therapeutic target in tumor cells with mTOR-mediated therapy resistance...