We also discuss the novel research goals that are being pursued in our department in the context of drug repurposing for airway infectious diseases including COVID-10 and mucormycosis.There has been a silent and underappreciated rise in drug-resistant invasive fungal infections (IFIs). Emerging ...
Fungal infections are now becoming a hazard to individuals which has paved the way for research to expand the therapeutic options available. Recent advances in drug design and compound screening have also increased the pace of the development of antifungal drugs. Although several novel potential molecu...
Project of repurposing benzimidazoles as anti-cancer drugs may increase the problem of resistance in the future [19]. Praziquantel is a cestodicidal agent used in both human and veterinary medicine. Whereas most of cestodes are highly host specific, Echinococcus spp. and Dibothriocephalus spp. ...
Drug Repurposing Identifies New Promising Treatment Options for Invasive Fungal DiseasesThe resistance of microorganisms to antimicrobial agents threatens the efficacy of drugs available for their treatment. This threat is worrisome with regard to fungal pathogens involved in aggressive invasive infections ...
Drug repurposing means finding new indications for a drug that has already been approved by regulatory agencies (such as FDA) for a specific disease. For drug repurposing, some research is based on computational approaches, and others are based on biological approaches. But the best approach is ...
Drug repositioning (also referred to as drug repurposing), the process of finding new uses of existing drugs, has been gaining popularity in recent years. The availability of several established clinical drug libraries and rapid advances in disease biology, genomics and bioinformatics has accelerated ...
Therefore, the repurposing of drugs already on the market, thus already passed the critical phase-1 safety studies, was implemented. Therefore, this study investigated the potential repurposing of 78 molecules tested/marketed clinically for AD and DM due to the tri-directional relationship between AD...
Repurposing itraconazole to the benefit of skin cancer treatment: A combined azole-DDAB nanoencapsulation strategy. Colloids Surf B. 2018;167:337–44. Article CAS Google Scholar Trombino S, Sole R, Curcio F, Malivindi R, Caracciolo D, Mellace S, et al. Microparticles made with silk ...
Drug repurposing FDA-approved drugs RdRp 3CLpro 1. Introduction The world is currently experiencing an emerging pandemic called COVID-19 (caused by SARS-CoV-2), to which no effective antiviral drugs or vaccines have been approved to date [1]. A recent hypothesis has proposed that COVID-19 ...
Mohamed Seleem, an associate professor of microbiology in Purdue's College of Veterinary Medicine, has used novel drug repurposing methods to discover two drugs that could have significant promise as a potent antimicrobial agent for treatment of both superficial and invasive infections. Seleem said that...