Topical preparations can be formulated with varying physico-chemical properties, as solid, semisolid or liquid. Micro-emulsion of drug is prepared and incorporated into emulgel, having novel topical drug delivery system as dual release control system. Micro-emulsions are micronized; thermodynamically ...
These properties make MOFs efficient hosts for various drugs [24, 25], allowing for extended release with tunable kinetics and improved bioavailability, meeting the demands of smart drug delivery systems. Drug release can be effectively controlled by introducing MOFs as the carrier [26, 27], and ...
Drug carrier DDS are systems incorporating drugs to improve their delivery and effectiveness by enhancing their bioavailability or changing their distribution properties. Three types of drug carrier are described: microcapsules,nanoemulsionsandnanoparticles[65]. Microfluidic platforms are particularly well suited...
Orally administered drugs must undergo dissolution in the gastrointestinal tract (GI) prior to absorption across the intestinal epithelium. The dissolution rate is not only dependent on the physicochemical properties of the drug, but also the physiological conditions in the GI tract. The in vivo ...
Oils, surfactant, hydrophilic cosurfactant, and drug compounds make up SNEDDS, an isotropic mixture that, when injected into an aqueous medium and gently stirred through the action of the digestive muscles in the stomach and intestines, forms a thin oil-in-water microemulsion14. This system denote...
Rue's active ingredients have antifungal and insecticidal properties that could prove beneficial to agriculture as well (7,8). Previous phytochemical investigation of this plant resulted in the isolation of a number of alkaloids and coumarins (9-11). Using an aqueous extract of the plant's ...
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The development of a smart microencapsulation system programmed to actively respond to environmental pH change has long been recognized a key technology in pharmaceutical and food sciences. To this end, we developed hollow microparticles (MPs) with self-controlled macropores that respond to environmental...
Some additional but important properties for addressing the designing of drug delivery are: how it reacts to water, whether it affects swelling, solubility, permeability, viscosity, and availability in the system. Other important properties are mechanical or physical properties, namely elasticity, viscos...
The HOMO-LUMO gap (HLG) values are considered to explore electronic properties and reactivity of the considered complexes. This quantity has the following operational equation: (4.2)HLG=ɛL−ɛH where ɛH and ɛL are the highest occupied molecular orbital (HOMO) and the lowest ...