Nature Reviews Drug Discovery volume 17, pages 97–113 (2018)Cite this article 64k Accesses 154 Altmetric Metrics details Abstract Small-molecule drug discovery can be viewed as a challenging multidimensional problem in which various characteristics of compounds — including efficacy, pharmacokinetics and...
The drug development process is a critical challenge in the pharmaceutical industry due to its time-consuming nature and the need to discover new drug pote
National Institute on Drug Abuse. “Understanding Drug Abuse and Addiction: What Science Says.” February 2016. Accessed May 2019. The Substance Abuse and Mental Health Services Administration. “Treatment Locator Map.” Accessed May 17, 2019. ...
15.3, and 22.6 µm particles, in addition, the particles of size 0.8 µm showed higher inflammatory lesions after 3 days, fewer infiltrations of fibroblasts near the depot after 4 weeks. On the contrary for higher particle size increase in drug deposition at the depot site was observed ov...
It’s a must have even if it’s not recommended by your nursing program. I have found it extremely beneficial to have right in my pocket at clinical, completing homework, and hopefully one day accepting a RN position as a new grad. All adverse reactions that are life threatening are in ...
Autoimmune diabetes in NOD mice: a genetic program interruptible by environmental manipulation. Immunol. Today 15, 115–120 (1994). CAS PubMed Google Scholar Mahler, M. & Leiter, E. H. Genetic and environmental context determines the course of colitis developing in IL-10-deficient mice. ...
Kas, ... Hugh Marston, in Neuroscience & Biobehavioral Reviews, 2019 1 Introduction 1.1 Brief history of drug discovery for neuropsychiatric disorders Mankind has been using psychoactive substances for millennia both for recreation and to alleviate suffering. Indeed, at least an acknowledgement of ...
Lifeng Kang, in Advanced Drug Delivery Reviews, 2018 4.8 Bioprinting for in vitro drug testing The abovementioned have demonstrated the capacity and competency of AM to create physical (non-cellular) models, which are anatomically accurate and functional – for predicting effects of drug action...
CRISPR-based drugs can theoretically manipulate any genetic target. In practice, however, these drugs must enter the desired cell without eliciting an unwanted immune response, so a delivery system is often required. Here, we review drug delivery systems
Protein kinases regulate nearly all aspects of cell life, and alterations in their expression, or mutations in their genes, cause cancer and other diseases. Here, we review the remarkable progress made over the past 20 years in improving the potency and