Digoxin overdose: Drug toxicity following inadvertent overdose in an elderly patient: case reportReactions Weekly
Digoxin MOA slow heart rate and strengthen beat to improve cardiac output; GOOD TO TREAT AFIB; Symptomatic HF; watch for bradycardia, diarrhea, n/v verapamil MOA calcium channel blocker Verapamil Contraindications 1. Severe CHF2. Sick Sinus Syndrome3. 2nd and 3rd degree Heart Blocks4. Blood Pre...
47 Off-target toxicity related to other type I BMP pathway receptors may also be a concern given that inhibition of ALK1 has been associated with vascular effects (telangiectasia, edema, and congestive cardiac failure),48 and ALK3 is implicated in the regulation of iron storage.49 It should ...
Examples of monitoring errors include inadequate frequency of monitoring of warfarin leading to an elevated international normalized ratio value associated with bleeding, and failure to respond promptly to symptoms suggestive of digoxin toxicity (eg, nausea, vomiting, and anorexia)....
Drug transport refers to the process facilitated by integral membrane proteins that move drugs and xenobiotics into and out of cells, often against a concentration gradient. These transporters play a crucial role in drug absorption, distribution, clearance, and toxicity within the body. ...
Together, these tools have made the zebrafish the organ- ism of choice for many researchers, as demonstrated by the marked increase in zebrafish publications in recent years. The yearly number of PubMed references on zebrafish has almost tripled in the past 5 years and increased more than ten...
2. CNS toxicity (reversed with FLUMAZENIL) Digoxin (4) 1. inhibits Na/K ATPase ==> increases intracellular Na ==> increase intracellular CaSE1. atrial tachycardia with block2. hyperkalemia3. serum level increases when administered with Quinidine or Verapamil4. hypokalemia precipitates digitalis ...
Elevated digoxin serum concentrations in patients receiving Clarithromycin and digoxin concomitantly have also been reported in post-marketing surveillance. Some patients have shown clinical signs consistent with digoxin toxicity, including potentially fatal arrhythmias. Serum digoxin concentrations should be caref...
Deferasirox pharmacogenetic influence on pharmacokinetic, efficacy and toxicity in a cohort of pediatric patients Pharmacogenomics, 18 (2017), pp. 539-554 CrossrefView in ScopusGoogle Scholar 50 J. Lee, H. Kang, J. Choi, N. Kim, M. Jang, C. Yeo, et al. Pharmacogenetic study of deferasirox...
To emulate intestinal drug absorption, transwell culture, in which the cell model of choice is cultured on a permeable filter support, constitute the most established paradigm (Fig. 1A). Developed more than 30 years ago, this model has been extensively used to study intestinal permeability.41, ...