Table 1 outlines various drugs with their generic and trade names, their role in relation to the CYP3A4 enzyme (inhibitor, substrate, or inducer), mechanism of action (MOA), therapeutic uses, and chemical structure (chemotype). Substrates like buspirone, cyclosporine, and tamoxifen rely on CYP...
No external funding was used in the preparation of this manuscript. Conflict of interest The authors whose names are listed immediately below report the following details of affiliation or involvement in an organization or entity with a financial or nonfinancial interest in the subject matter or mate...
Methods for identifying and treating cancers that are DNA repair, such as homologous recombination (HR) repair, defective or sensitive to PARP inhibitors or platinum-based therapy. In some aspects, DNA repair, such as HR repair, defective cancers are treated with a PARP inhibitor therapy or cispl...
Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults, with an incidence that increases with age, and a generally poor prognosis. The disease is clinically and genetically heterogeneous, and recent advances have improved our understanding of the cytogenetic abnormalities an...
Drug-induced liver injury (DILI) remains an important, yet challenging diagnosis for physicians. Each year, additional drugs are implicated in DILI and thi
Many of the tweets included abbreviations or acronyms for ADRs and drug names that are ambiguous with general terms. Considering that there is an entirely different vocabulary of abbreviations and slang words adopted by Twitter users, we believe that a custom-built lexicon of abbreviations and ...
The probability of sensitivity to 20 anticancer drugs of 20 HNSC cell lines. Drugs whose names are shown in green have been studied for the treatment of HNSC. The probability higher than 0.5 means that the corresponding row drug may be a novel repositioned drug for the treatment of the corre...