Principles of drug movement in the body. In: Riviere JE, ed. Comparative pharmacokinetics: principles, techniques and applications. 2nd ed. Ames, Iowa: Wiley- Blackwell, 2011;13-25.J.E. Riviere, Principles of drug movement in the body, in Comparative Pharmacokinetics - Princi- ples, ...
• Absorption refers to movement of the drug across body barriers (primarily the skin, respiratory tract, and gastrointestinal tract) into the central blood compartment (i.e., systemic circulation). The rate at which this passage occurs c...
an alteration in blood flow to the intestine; change in drug metabolism (breakdown) by the intestine; increased or decreased intestinal motility (movement); alterations in stomach acidity, and a change in the bacteria that reside in the intestine. ...
Transport through cell layers by movement directly through the cell cytoplasm (the transcellular pathway), perhaps via membrane vesicles called caveoli, in contrast to transport between cells via the tight junctions (the paracellular pathway).
ethical drug- a drug that is available only with written instructions from a doctor or dentist to a pharmacist; "he told the doctor that he had been taking his prescription regularly" prescription drug,prescription medicine,prescription medicament,medication,medicinal drug,medicine- (medicine) something...
An important step in all these processes is the movement of drug molecules through cellular barriers (e.g., the intestinal wall, the walls ofblood vessels, the barrier between the bloodstream and thebrain, and the wall of the kidney tubule), whichconstitutethe main restriction to the free diss...
Studies in mice have supported the idea that antibody-mediated responses can halt active movement and/or result in complement-mediated cytotoxicity of sporozoites in the skin to prevent infection [23–25,78]. Hence, while one could contemplate strategies to activate complement or immune cells that ...
In terms of cellular models, there has been a movement towards a reduction in animal testing to determine the efficacy and toxicity of a drug candidate on the human body, partially due to erroneous pharmacokinetic predictions arising from species differences [236,237]. This resulted in an ...
a每当夜幕降临 Whenever the curtain of night arrives[translate] a运动对人是好的,它能使身体更强壮,身心更健康 The movement to the human is good, it can cause the body to be stronger, the body and mind is healthier[translate] a对于一定物力相结合的人力进行合理的培训、组织和调配,使人力、物力经...
The invention features a catheter and methods for delivering drug to tissue at a desired location of the wall of a body lumen. The catheter is constructed for insertion in a body lumen and has a catheter shaft and an expandable portion mounted on the catheter shaft. The expandable portion is...