Principles of drug movement in the body. In: Riviere JE, ed. Comparative pharmacokinetics: principles, techniques and applications. 2nd ed. Ames, Iowa: Wiley- Blackwell, 2011;13-25.J.E. Riviere, Principles of drug movement in the body, in Comparative Pharmacokinetics - Princi- ples, ...
New perspectives on the theory of permeability and resistance in the study of drug transport and absorption Permeability coefficient ( P ) expressed as distance per unit time has been commonly interpreted to represent the velocity of drug movement across a hetero... WL Chiou - 《Journal of Pharma...
nose, and perspiration. The addict lapses into a restless, fitful sleep and, upon awakening, experiences acontractionofpupils, gooseflesh, hot and cold flashes, severe leg pains, generalized body aches, and constant movement. The addict then experiences severeinsomnia,nausea,vomiting, anddiarrhea. ...
An important step in all these processes is the movement of drug molecules through cellular barriers (e.g., the intestinal wall, the walls ofblood vessels, the barrier between the bloodstream and thebrain, and the wall of the kidney tubule), whichconstitutethe main restriction to the free diss...
(i.e., the sustained release phase), the more complex structure of the copolymer probably leads to significant steric hindrance phenomena that restrict drug’s movement within the swollen NPs’ structure and hence, restrict its interactions with the molecules of the dissolution medium leading to ...
Because the development of drug delivery technology aims at precise control of the movement of the drugs in the body,pharmacokinetics, i.e. the mathematical analyses of the movement of drug at whole body, organ, and cell levels play important role in its development [9,10]. The significance ...
There is now a growing movement that views a number of behaviours as potentially addictive including many that do not involve the ingestion of a drug (such as gambling, sex, exercise, videogame playing and Internet use). This paper argue... Mark Griffiths - 《Journal of Substance Use》 被引...
Transport through cell layers by movement directly through the cell cytoplasm (the transcellular pathway), perhaps via membrane vesicles called caveoli, in contrast to transport between cells via the tight junctions (the paracellular pathway).
Much like the interplay of transport and metabolic enzymes at the intestinal barrier, these transporters also have a “gatekeeper” function in the drug movement from the blood into hepatocytes; they regulate both the number of drugs available for metabolism by liver enzymes and the subsequent ...
During the process, the deflection of the cantilever and the movement of the piezo tube are recorded to produce so-called force curves. Figure 1B shows a schematic diagram of a force curve obtained during the approach-retract cycles. A force curve contains two com- ponents: an approach ...