As the number of diseases has been increasing, there is a shift in the research environment in pharmaceutical companies toward the faster screening of drug candidates. Drug repositioning is an effective strategy to fasten the search of potential drug candidates. Although there are many computationally...
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Despite these limitations, to our knowledge, our study is the first to summarize evidence on the diagnostic accuracy of rapid antigen tests for pneumococcal meningitis. We used rigorous methodology, including a comprehensive search and a pre-specified analysis plan. We conducted many subgroup and sens...
DRUG RESISTANCE: THE STATUS OF THE PROBLEM AND THE SEARCH OF WAYS TO OVERCOME IT (literature review and own research) The ability of multicellular associates to undergo changes that provide increased resistance to adverse environmental factors determines the development of... D Zabolotnyi,M Sambur...
Analysis of the toxicity of chemotherapeutic drugs is one of the main tasks of clinical pharmacology. Decreased viability of tumor cells may reflect two important physiological processes, namely the arrest of proliferation associated with disturbances in
Methods and results: Bacterial resistance continually increased because of wide use even abuse, therefore, it is focus to search for new and effective antibacterial agents. There are two strategies: the first one is direct antibacterial such as structure modification of present antibacterial agents, ...
we analyzed the selected network consisting of the fist-order KG and second-order KG. We observed that the supporting KG did act as a bridge between drugs and proteins but we also found that the selected network seemed to bring in a lot of noises (Fig.6b). In the betweenness centrality ...
It is no news that this viral attack has left the world gyrating in search of a vaccine and cure. Relentless research efforts targeting small molecules have led to significant progress in man's struggle to overcome this common enemy. In 2020, a small molecule known as niclosamide has shown ...
A total of 36 overlapping grids (search spaces) were designed to cover the entire surface of an HN monomer (represented in grey), and simulations were run on each of them. Left: volume of the 36 grids combined. Right: volume of a single grid centred on the HN active site. (d) ...