Important drug interactions with four agents or classes (statins, warfarin, factor Xa inhibitors, and calcium channel blockers) are discussed.doi:10.1111/jgs.14870Susan E. MerelDivision of General Internal Medicine Department of Medicine University of Washington Seattle WashingtonDouglas S. Paauw...
metabolism, or elimination of a drug. Drug interactions also may occur when two drugs that have similar (additive) effects or opposite (canceling) effects on the body are administered together. For example, there may be major sedation when two drugs that can cause sedation are taken simultaneousl...
Dangerous Interactions When Drinking Alcohol Alcohol is a common substance that may interfere with a variety of drugs. Interactions with drugs may cause nausea, vomiting, fainting, headaches, dizziness, changes in behavior, and blood pressure changes. The effects of many other drugs are increased whe...
Drug-drug interactions with commonly used medications representing the drug classes of antidepressants (escitalopram and duloxetine), antihypertensives (amlodipine), diuretics (furosemide), anxiolytics/sleep aids (alprazolam and zolpidem), and oral contraceptives (norethindrone, ethinyl estradiol [EE] plus ...
with drugs that are substrates, inducers, or inhibitors of CYP enzymes or excreted through the kidneys. However, caution is advised, and healthcare providers should be aware of this new field of DDIs in COVID-19 if any observation should be reported, (e.g., interactions with COVID-19 ...
Drug interactions. (i) This section must contain a description of clinically significant interactions, either observed or predicted, with other prescription or over-the-counter drugs, classes of drugs, or foods (e.g., dietary supplements, grapefruit juice)…[i]nteractions that are described in ...
TxGNN identifies tretinoin as the top candidate for treating Ehlers–Danlos syndrome. TxGNN’s predictive rationale is rooted in the drug’s interactions with albumin (ALB) andALDH1A2, which aligns with medical insights about Ehlers–Danlos syndrome with regard to collagen loss and inflammation miti...
Pharmacological profile of the novel antiepileptic drug candidate padsevonil–interactions with synaptic vesicle 2 proteins and the GABAA receptor. J. Pharmacol. Exp. Ther. 372, 1–10 (2020). Article CAS PubMed Google Scholar Leclercq, K. et al. Pharmacological profile of the antiepileptic drug...
However, ritonavir may cause drug-drug interactions (DDIs) due to its interactions with various drug-metabolizing enzymes and transporters, including cytochrome P450 (CYP) 3A, CYP2D6, and P-glycoprotein transporters. To better understand the extent of DDIs (or lack thereof) of nirmatrelvir; ...
Acute interactions: dizziness, flushing, nausea, stomach bleeding, orhostatic hypotension, respiratory depression; chronic interactions: liver damage