Additional InteractionsAdditional pharmacodynamic interactions that can occur with the use of ziprasidone include sedation, hypotension, and dopamine antagonism. Given the primary CNS effects of ziprasidone, caution should be used when it is taken in combination with other centrally acting drugs because of...
Drug InteractionsDrugs undergoing CYP450 metabolism Sotalol is primarily eliminated by renal excretion; therefore, drugs that are metabolized by CYP450 are not expected to alter the pharmacokinetics of Sotalol. Sotalol is not expected to inhibit or induce any CYP450 enzymes; therefore, it is not ...
Male, old age and polypharmacy increased the likelihood of potential drug–drug interactions. The most frequently prescribed drugs responsible for potential drug–drug interactions included pioglitazone, dihydrocodeine, thalidomide, sotalol, amiodarone and amlodipine. The predominant potential adverse outcome of...
1、Drug Interactions 2 Example Excessive terfenadineLethal arrhythmias Ketoconazole is an enzyme inhibitor Terfenadine + ketoconazole: Increase the serum concentration of terfenadine In 1998, terfenadine was removed from market. 3 Outline Introduction - Definition - Drugs likely to be involved in inter 2...
Moreover, multimorbidity is common in cardiovascular disease patients and is often associated with polypharmacy, which increases the likelihood of clinically relevant drug-related interactions. These, in turn, can lead to reduced drug efficacy, medication-related harm (adverse drug reactions, longer ...
Amiodarone (HCl) is known to interact with other drugs, the details of drug interactions is as follows: Severity N/AHalofantrine (HCl) Interaction of Halofantrine (HCl) with Amiodarone (HCl)Terfenadine Interaction of Terfenadine with Amiodarone (HCl)Dextromethorphan Interaction of Dextromethorphan...
-Pharmaceuticalinteractions •High-riskclinicalsettings 3 联合用药(Concomitantdrugs)•Concomitantdrugsaretwoormoredrugsused orgivenatoralmostatthesametime(one aftertheother,onthesameday,etc.).•同时或在一定间隔时间内使用两种或两种以上的药物,称为联合用药(Concomitantdrugs)。•联合用药品种偏多,使药物...
It has proven safe in patients with acute myocar- dial infarction, even those who have relative contraindications to β-blockers [87]. Typically, the ... MS Pergolini - 《Clinica Terapeutica》 被引量: 34发表: 2009年 Angiotensin receptor blockers and drug-drug interactions. It has proven safe...
, combining two medications that are central-acting but with different mechanisms, such as a TCA and an opioid analgesic, might result in better pain relief than monotherapy. Combination drug therapy may improve pain relief, but it also increases adverse effects and potential drug interactions....
class III drugsnot only exhibit importantantiarrhythmicactions but also have the potential to induce life-threatening proarrhythmias, typicallyTDP. Therefore, anesthesiologists should be familiar with theadverse effectsof these drugs and their interactions with other Q-T interval–prolonging drugs and ...