Drugs that depend on these enzymes for their metabolism are prone to drug interactions when coadministered with rifampin. A novel, clinically relevant drug interaction is described between rifampin and mycophenolate mofetil (MMF), a cornerstone immunosuppressive molecule used in solid organ transplantation...
This study evaluated the pharmacokinetic interactions, safety, and tolerability of letermovir when coadministered in healthy subjects with mycophenolate mofetil (MMF), which is the morpholinoethyl ester prodrug of mycophenolic acid (MPA).Methods: This was an open-label trial in 14 healthy female ...
mycophenolatemofetil (MMF),prednisone,sirolimus, andtacrolimusare common immunosuppressive agents used clinically to manage transplant patients. Drug–drug interactions between “azole” antifungal drugs such asfluconazole,voriconazole,itraconazoleand cyclosporine,everolimus, sirolimus, and tacrolimus are well ...
Drug interactionsElderlyPregnancyZafirlukast, pharmacokineticsIn the past decade, fludarabine has had a major impact in increasing the effectiveness of treatment... DV Gandhi,W Plunkett - 《Clinical Pharmacokinetics》 被引量: 798发表: 2002年 Clinical Pharmacokinetics and Pharmacodynamics of Mycophenolate in...
For most antirheumatic drugs a vast number of interactions have been described but only a minority with clinical relevance. Several potentially important drug interactions exist for non-steroidal anti-inflammatory drugs (NSAIDs), methotrexate, azathioprine, mycophenolate-mofetil and especially for ...
●An 18-year-old female patient after allogeneic peripheral hematopoietic stem cell transplantation took cyclosporine 100 nag once every 12 hours, mycophenolate mofetil 1.0 g once every 12 hours, and methylprednisolone 8 mg once every 12 hours, and the plasma concentration of cyclosporine was maintaine...
P. et al. Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics. Nature 407, 340–348 (2000). Article CAS PubMed Google Scholar Schlunzen, F. et al. Structural basis for the interaction of antibiotics with the peptidyl transferase centre ...
Interactions at the level of basolateral transporters typically decrease the clearance of the victim drug, causing higher systemic exposure. Interactions at the apical level can also lower drug clearance, but may be associated with higher renal toxicity, due to intracellular accumulation. Whereas the ...
Herbs are often administered in combination with therapeutic drugs, raising the potential of herb-drug interactions. An extensive review of the literature
Drug Interactions Comments More What are corticosteroids? Corticosteroids are steroid hormones that are either produced by the body or are man-made. Systemic corticosteroids refer to corticosteroids that are given orally or by injection and distribute throughout the body. It does not include cortic...