Apixaban, a direct oral anticoagulant, has emerged over the past few years because it is considered to have a low risk of drug-drug interactions compared to vitamin K antagonists. To better characterize these interactions, we systematically reviewed studies evaluating the drug-drug interactions ...
There is also a theoretical interaction between CBD and the direct-acting oral anticoagulants like apixaban and rivaroxaban, based on the CYP3A enzyme (and P-gp efflux transporter), potentially increasing the risk of bleeding. While no cases of interactions between CBD and these drugs have been ...
Limited PK data exist regarding interactions between dronedarone and the factor Xa inhibitors. Given that: 1) rivaroxaban and apixaban are both substrates for CYP3A4 and P-gp; and 2) edoxaban and betrixaban are substrates for CYP3A4, increases in systemic exposure with these agents is expected ...
Rivaroxaban and apixaban did not exhibit any interactions at the projected therapeutic dosage range when combined with any of the routinely used drugs. However dabigatran at a fixed concentration of 1 g/ml combined with the commonly used drugs at a fixed concentration of 0.1 g /ml or 1 g/ml...
Drug interactions with apixaban: A systematic review of the literature and an analysis of VigiBase, the World Health Organization database of spontaneous s... , has emerged over the past few years because it is considered to have a low risk of drug-drug interactions compared to vitamin K anta...
Apixaban: Indications, Drug Interactions & Side Effects Edoxaban vs. Apixaban Apixaban: Mechanism of Action & Pharmacokinetics Warfarin Mechanism of Action3:35 Warfarin and Vitamin K: Relationship and Interaction Ch 5.Overview of Heparinoid Drugs ...
42.In vitro drug-drug interactions with perospirone and concomitantly administered drugs in human liver microsomes. 机译:在人肝微粒体中与Perospirone和伴随给药的药物的体外药物相互作用。 作者:Shimakura J;Tani N;Mizuno Y;Komuro S;Kanamaru H 期刊名称:《European journal of drug metabolism and pharmaco...
(2022) Ferri et al. Pharmaceutics. The direct oral anticoagulants (DOACs), dabigatran, rivaroxaban, apixaban, and edoxaban, are becoming the most commonly prescribed drugs for preventing ischemic stroke in patients with non-valvular atrial fibrillation (
The recently approved oral direct thrombin inhibitor dabigatran, along with the emerging oral anti-factor Xa inhibitors, rivaroxaban, apixaban, and edoxaban, have been developed to address many of the shortcomings of warfarin therapy. As warfarin is associated with extensive food and drug interactions,...
Interactions at the apical level can also lower drug clearance, but may be associated with higher renal toxicity, due to intracellular accumulation. Whereas the importance of glomerular filtration in drug disposition is largely appreciated among clinicians, DDIs involving renal transporters are less well...