John’s wort (SJW) to cause drug interactions. At that time, SJW had been identified as an inducer of cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp). We discussed the interactions with alprazolam, oral contraceptives, and several antiretroviral drugs. In each case, SJW was shown...
DRUG-food interactionsCRANBERRY juiceMENTAL illnessURINARY tract infectionsThis article examines the potential interactions between alprazolam, a medication used for anxiety, and cranberry and pomegranate juices. These juices can inhibit the enzyme that metabolizes alprazolam, potentially leading to increased...
Among medications at risk for combined pharmacokinetic-pharmacodynamic interactions, nefazodone is an antidepressant drug that increases the plasma concentrations of BDZ due to its inhibition activity on CYP3A4, especially for short half-life benzodiazepines (midazolam, alprazolam and triazolam) [43,44]...
Interactions There are several drugs that Alprazolam interacts with which can be very dangerous. For this reason, it is important to tell your doctor about all the medicines you take including street drugs and herbal supplements. Alcoholic drinks must never be consumed by individuals who are on Al...
The same is true of cannabidiol and tizanidine interactions. Sedatives and CBD Moderate interactions are possible when mixing sedatives and quality CBD oil. Sedatives include benzodiazepines, such as alprazolam (Xanax), lorazepam (Ativan), diazepam (Valium), morphine, and others, as well as ...
This chapter discusses the regulatory aspect of dietary herbal products and the interaction of herbal supplements with therapeutic drugs. The pharmacology and effects on drug-metabolizing enzymes of garlic (Allium sativum) and the interactions of garlic supplements with dextromethorphan, alprazolam, ...
Herbs are often administered in combination with therapeutic drugs, raising the potential of herb-drug interactions. An extensive review of the literature identified reported herb-drug interactions with clinical significance, many of which are from case reports and limited clinical observations. Cases have...
Substrates: alprazolam, amlodipine, atorvastatin, cyclosporine, diazepam, estradiol, simvastatin, sildenafil, verapamil, zolpidem Below is an additional list of common drug-drug interactions involving the cytochrome P-450 system that clinicians should be aware of: ...
In summary, nifedipine metabolism can be significantly affected by different nutrients, with the major ones investigated thus far being SJW, Ginkgo biloba, and grapefruit juice. These interactions are likely to be mediated, at least in part, by the CYP3A4 enzyme, and considering the multiplicity...
Drug-drug interactions (DDIs) caused by the co-administration of multiple drugs can lead to alteration in the exposure of the victim drug, raising safety or effectiveness concerns. Assessment of the DDI potential starts with in vitro experiments to determine kinetic parameters and identify risks ...