The pharmacodynamic interaction of interest with ziprasidone is its potential to prolong the QTc interval and its combination with other medications that can cause the same cardiac conduction effect. Prolongation of the QTc interval is associated in some drugs with the ability to cause torsades de poi...
Proarrhythmic events were more common in Sotalol treated patients also receiving digoxin; it is not clear whether this represents an interaction or is related to the presence of CHF, a known risk factor for proarrhythmia, in the patients receiving digoxin. Both digitalis glycosides and beta-...
However, a number of drugs (such as digoxin) have been reported to interact with sotalol pharmacodynamically.If concurrent use of a class III antiarrhythmic agent and another drug cannot be avoided or no published studies for that particular drug interaction are available, caution should be ...
A drug interaction can result in either an increased or decreased effect of the object drug. E.g., terfenadine + ketoconazole object drugp 5、recipitating drug the objects drugs (目标药物):(目标药物):在联合在联合 用药中,药效发生变化的药物用药中,药效发生变化的药物 the precipitating drugs (促...
DDI Prevalence and Implicated Cardiovascular Medicines For an interaction to be clinically relevant, plasma concentrations of the victim drug should either be increased above (toxicity) or decreased below (lack of efficacy) the therapeutic window, with the likelihood of clinical relevance ie out-of- ...
SDrTDi context.bThe density curve of AUROC and AUPRC of KDDANet with different γ setting and permutation test in SDiTDr context.cComparison of AUROC and AUPRC of KDDANet with PPA, SNPLS, comCHIPER, and DGPsubNet.dAUROC and AUPRC of KDDANet with different types of gene interaction ...
).•同时或在一定间隔时间内使用两种或两种以上的药物,称为联合用药(Concomitantdrugs)。•联合用药品种偏多,使药物相互作用的发生率增加,影响药物疗效或毒性增加。因此在给病人用药时,应十分小心,应尽量减少用药种类,减少药物相互作用引起的药物不良反应。2021/6/3 4 Introduction •Druginteractionmeansthe ...
Pharmacogenomics, pharmacokinetics and pharmacodynamics: interaction with biological differences between men and women 10.1111/bph.12362 Google Scholar [3] I.J. Onakpoya, C.J. Heneghan, J.K. Aronson Post-marketing withdrawal of 462 medicinal products because of adverse drug reactions: a systematic re...
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inhibits interaction of acetylcholine (ach) at bronchial receptors, results in decreased cyclic guanosin monophosphate and bronchodilation indications: persistent bronchospasm, copd exacerbation contraindications: hypersensitivity to ipratropium, atropine, alkaloids, peanuts dose & route: adult: 250 - 500mcg ...