A drug–drug interaction (DDI) can result from changes in the pharmacokinetics (PK) of a drug or its metabolites due to alteration in absorption, distribution, metabolism or excretion, or as a result of amplification or disruption of a pharmacodynamic (PD) effect. ...
These may be due to complex formation of the probe and drug, or the interaction of the protein-probe complex and drug. The association constant for ibuprofenlysine increased with increasing protein concentration. These findings suggest a sharing of one ibuprofenlysine molecule by more than one ...
C. (1980) Interaction of indomethacin and ibuprofen with lithium in manic patients under a steady-state lithium level. J. Clin. Psychiatr., 41, 397–8. CAS Google Scholar Rawles, J. M. (1982) Antagonism between non-steroidal anti-inflammatory drugs and diuretics. Scott. Med. J., 27, ...
Drug-drug interaction. This is when a medication reacts with one or more other drugs. For example, taking acough medicine(antitussive) and a drug to help yousleep(sedative) could cause the two medications to affect each other. Drug-food/drink interaction. This is when something you eat or...
There are several mechanisms by which drugs interact with other drugs, food, and other substances. An interaction can result when there is an increase or decrease in: the absorption of a drug into the body; distribution of the drug within the body; ...
Various bulk and surface parameters such as critical micelle concentration (CMC) of the mixtures, micellar mole fraction ( X ), interaction parameter ( β ) and free energies were calculated using Clint, Rubingh, Rosen and Maeda models. In aqueous solutions, all the mixtures show synergistic ...
Drug-drug interaction (DDI) is an important topic for public health and thus attracts attention from both academia and industry. Here we hypothesize that clinical side effects (SEs) provide a human phenotypic profile and can be translated into the develo
The net result of a drug interaction may be: enhancement of effects of one or other drug (hence increasing the risk of an ADR occurring); development of totally new effects not seen when either drug is used alone; inhibition of effect of one drug by another; no change in the net result...
R. et al. Lacosamide Inhibition of NaV1.7 channels depends on its interaction with the voltage sensor domain and the channel pore. Front. Pharmacol. 12, 791740 (2021). CAS PubMed PubMed Central Google Scholar Javanbakht, H. in Phenotypic Drug Discovery: Recent Advances and Insights from ...
Interindividual variability in ibuprofen pharmacokinetics is related to interaction of cytochrome P450 2C8 and 2C9 amino acid polymorphisms. Clin Pharmacol Ther 2004;76:119–127. CAS Google Scholar Hong X, Zhang S, Mao G, Jiang S, Zhang Y, Yu Y, Tang G, Xing H, Xu X. CYP2C9*3 ...