These may be due to complex formation of the probe and drug, or the interaction of the protein-probe complex and drug. The association constant for ibuprofenlysine increased with increasing protein concentration. These findings suggest a sharing of one ibuprofenlysine molecule by more than one ...
The increase in bazedoxifene plasma concentrations when combined with ibuprofen versus bazedoxifene alone is unlikely to be clinically significant. The lack of interaction between bazedoxifene and ibuprofen suggests that they may be coadministered without dose adjustment....
There are several mechanisms by which drugs interact with other drugs, food, and other substances. An interaction can result when there is an increase or decrease in: the absorption of a drug into the body; distribution of the drug within the body; alterations made to the drug by the body...
Chignell, C. F. and Stark Weather, D. K.(1971) Optical studies of drug protein complexes V. The interaction of phenylbutazone, flufenamic acid, and dicoumarol with acetyl salicylic acid treated human serum albumin.Mol. Pharmacol.,7, 229–37. PubMedCASGoogle Scholar Chlud, K.(1976) Inves...
Drug-food/drink interaction. This is when something you eat or drink affects a drug. For instance, it can be dangerous to drink alcohol while you're on certain medications. Somevitaminsanddietary supplementsinteract with medicines, too.
The mutual effects of ibuprofen (IBU) and the nonionic surfactant, polysorbate 40 (Tween40, Tw40) were investigated. The parameters of interest were the critical micelle concentration of the surfactant and the drug distribution between the micellar and external aqueous phases. These were studied at...
Alpinia officinarum Hance Indomethacin Herb-drug interaction Pharmacokinetics Tissue distribution Excretion 1. Introduction Non-steroidal anti-inflammatory drugs (NSAIDs) are widely applied worldwide and used by more than 30 million people every day, accounting for about 60% of OTC market shares of the...
HSA is a repository and carrier for various unrelated ligands [127]. Exploring the effect of HSA interaction with Zn2+/Cu2+on plasma-unsaturated FAs, Nemashkalova et al. [128] found that loading HSA with Zn2+decreased the nmax values by 0.3–1.5, whereas saturation with Cu2+resulted in...
OBJECTIVE: To compare comprehensiveness and accuracy of drug interaction information in the German summary of product characteristics (SPC) with current ev... V Bergk,WE Haefeli,C Gasse,... - 《European Journal of Clinical Pharmacology》 被引量: 191发表: 2005年 ...
Lack of significant interaction between low dose methotrexate and ibuprofen or flurbiprofen in patients with arthritis. J Rheumatol 1990; 17: 1008–10PubMed 34. Anaya J-M, Fabre D, Bressolle F, et al. Effect of etodolac on methotrexate pharmacokinetics in patients with rheumatoid arthritis. J ...