The Drug Interaction Database (DIDB®) has the largest manually curated collection ofhumanin vitroandclinical (in vivo)data available. Learn more 8180,808080 citations with 818080,808080 entries 818080 NDA/BLAs with 81,808080 entries From all relevant publications (citations) and FDA regulatory ...
Hachad, H, Ragueneau-Majlessi, I, Levy, RH Metabolism and transport drug interaction database: a web-based research and analysis tool. In: David Rodrigues, A eds. (2008) Drug–Drug Interactions. Informa Healthcare, New York, pp. 567-579...
Drug Gene Interaction Database (DGIdb) web resource43 was used to retrieve FDA-approved drugs that interact with 25 genes including the top ranked nodes of the core network (Table 2) and the identified TFs. We found 10 out of the 25 genes (7 upregulated DEGs and 3 TFs) have 64 intera...
they are marked as "unapproved" in the database. In addition, as drug listing updates are obligatory only twice a year, FDA may not yet have been notified of recent changes before updating the NDC Directory. As a result, drug labeling on the website is not ...
FDA thus recommends that the drug-drug interaction potential of a metabolite as a substrate or inhibitor of major drug transporter should be assessed on a case-by-case basis using the same principles and strategies that are applied for the parent drug....
Aim:To characterize concordance between clinically relevant drug–drug interactions (DDIs) related to CYP2C19, CYP2D6 and CYP2C9 and their analogous gene–drug interactions (GDIs) in US FDA-approved drug labeling.Methods:We selected prototypical CYP2C19, CYP2D6 and CYP2C9 inhibitors and abstracted...
DGIdb 3.0: A redesign and expansion of the drug-gene interaction database. Nucleic Acids Res. 2018, 46, D1068–D1073. [Google Scholar] [CrossRef] [PubMed] [Green Version] Mendez, D.; Gaulton, A.; Bento, A.P.; Chambers, J.; De Veij, M.; Felix, E.; Magarinos, M.P.; ...
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potential interaction between acetriptan and magnesium stearate. However, at levels representative of the final formulation, the interaction was found to be negligible. Furthermore, the potential interaction between acetriptan and magnesium stearate is limited by only including extragranular magnesium ...