From the set of DTs, we converted gene symbols to UniProt protein accessions using the identifier mapping scheme provided by the UniProt database19, obtaining the set of 268 DT proteins reported in Supplementary Material S1. Construction of the interaction network of drug targets. PINs are ...
REAGENT or RESOURCESOURCEIDENTIFIER Antibodies Rabbit polyclonal anti-p-Akt (Ser473) Cell Signaling Technology Cat#9271; RRID: AB_329825 Rabbit polyclonal anti-Akt Cell Signaling Technology Cat#9272; RRID: AB_329827 Rabbit polyclonal anti-p-TEK (Tyr992) Cell Signaling Technology Cat# 4221; RRID:...
BMC Medical Research Methodology (2016) 16:166 Page 2 of 11 (Continued from previous page) Trial registration: ClinicalTrial.gov identifier: NCT01501591 (registered December 25, 2011). Keywords: Balanced placebo design, Randomized placebo-controlled trials, Biased drug effect size, Drug placebo ...
Prediction and validation of new compiled DTI dataset. To enhance the diversity of benchmark datasets and facilitate more rigorous assessment for DTI prediction algorithms, we have compiled a new DTI dataset with PubChem CID identifier for drugs and UniProt identifier for targets. First, we ...
Cancer continues to be one of the most difficult global healthcare problems. Although there is a large library of drugs that can be used in cancer treatment, the problem is selectively killing all the cancer cells while reducing collateral toxicity to he
Section 804 Importation Plan, or “SIP”– A SIP is an FDA-approved plan for the importation of eligible drugs. Section 804 Serial Identifier, or “SSI”– An SSI is a serial number assigned by the Foreign Seller and placed on packages to be imported under a S...
no suitable reference region is clearly established, although the centrum semiovale is being evaluated as a pseudo-reference region [217]. Both11C-UCB-J and18F-UCB-H have fast kinetics. However,11C-UCB-J has a higher dynamic range and significantly higher BPNDin NHPs and human and has calcu...
BMC Medical Research Methodology (2016) 16:166 Page 2 of 11 (Continued from previous page) Trial registration: ClinicalTrial.gov identifier: NCT01501591 (registered December 25, 2011). Keywords: Balanced placebo design, Randomized placebo-controlled trials, Biased drug effect size, Drug placebo ...
phase II clinical trial, and then phase II trial was designed to evaluate the efficacy of TCP at recommended dose in patients with AML or MDS. In addition, two other clinical trials have been carried out for the combination of TCP and ATRA (ClinicalTrials.gov Identifier: NCT02261779; NCT...
Leukemia is a kind of hematological malignancy originating from bone marrow, which provides essential signals for initiation, progression, and recurrence of leukemia. However, how to specifically deliver drugs to the bone marrow remains elusive. Here, we