N. et al. Extension of in vivo half-life of biologically active molecules by XTEN protein polymers. J. Control. Release 240, 52–66 (2016). CAS PubMed Google Scholar Gebauer, M. & Skerra, A. Prospects of pasylation® for the design of protein and peptide therapeutics with extended ...
Life-threatening signs (hemophagocytosis with bone marrow failure, encephalitis, severe hepatitis, renal failure, respiratory failure): steroids generally associated with IVIG at a dose of 2 g/kg over 5 days. The IVIG should not be proposed without associated steroids. These treatments to be conduc...
Medication errors are a significant health burden causative to over half of all ADEs among hospitalized patients4. Globally, the price related to medication errors has been 42 billion $/year, not considering lost wages, productivity, or health care prices5. Potential adverse drug event (PADE) ...
also showed that this transdermal system has about 4 times longer elimination half-life than oral delivery with better bioavailability (2.03 times higher than oral route) over 48 h. The observed drug release was rapid, accompanied by subsequent sustained release. Hence, carbopol-based transgel ...
The terminal half-life is about 3–4 h and it is eliminated mainly in an unmodified form, more than 70% through the kidney. However, pharmacokinetics of high dose baclofen may vary from the conventional 80 mg daily [80]. Time-to-peak plasma levels and plasma half-lives were ...
[130]. However, curcumin also possesses several disadvantages in therapeutic use such as poor solubility in liquids, compound instability, short half-life in plasma, inefficient tissue absorption, and light-sensitive [129,135]. To overcome these disadvantages, reducing curcumin to the nano scale may...
natural drugs also have the advantages of abundant resources, low cost, and easy availability, making them an important source of new drug development. More than half of the new chemical entity drugs developed internationally are directly or indirectly derived from natural medications. Natural medicatio...
English TitleDrugstore in Another World: The Slow Life of a Cheat Pharmacist Aliases Romaji TitleCheat Kusushi no Slow Life: Isekai ni Tsukurou Drugstore Furigana Titleチートくすしのスローライフ いせかいにつくろうドラッグストア Japanese Titleチート薬師のスローライフ ～異世界に作ろうド...
Despite their high efficacy, the long circulation half-life and non-specific binding of cytotoxic ADCs can result in systemic toxicity. In addition, standard ADCs do not provide an image-guided mode of administration. Here, we have developed a two-component, two-step, pre-targeting drug ...
During the first half of the 20th century, drug discovery largely focused on the fight against infectious diseases. Whereas, in 1900, the average life expectancy at birth was 47 years even in the industrialized world, this had increased to 68 years in the USA by 1950,122 largely attributable...