Urinary flow is often obstructed by calculi, which results in the rise of intra-ureteral pressure, leading to pain. An analgesic and an antispastic are prescribed for the pain. However, the use of the analgesic is only a temporary symptomatic therapy for the pain, and is not expected to ...
Drug treatments for lower urinary tract symptoms secondary to bladder outflow obstruction: focus on quality of life. Drugs. 2003;63:1947-1962.MacDonald Donald,McNicholas Thomas A.Drug treatments for lower urinary tract symptoms secondary to bladder outflow obstruction: focus on quality of life....
Use of the non-opiate analgesic drug flupirtine for the treatment of overactive bladder and associated diseases including urge incontinence, urinary flow problems as a result of prostate hyperplasia and irritable bowel syndrome The present invention is directed to the prevention, reversal and medical ...
1433. Impact of 2019 US Food and Drug Administration (FDA) Guidance on Developing Drugs for Urinary Tract Infection (UTI) on the Perceived Efficacy of Anti... BACKGROUND. In 2019, the FDA issued guidance on drug development for treatment of UTIs. To explore the impact of this guidance, we...
12.Safety Pharmacology for Other Organs Safety pharmacology studies for organ systems other than those included in the core battery can also be evaluated depending on the therapeutic indication and adverse findings in the toxicity studies. This includes the...
the formation of toxic metabolites from non-toxic parent substances; e) the kidney's concentrating mechanisms, which can increase urinary and interstitial concentrations of non-absorbed products; f) the high metabolic rate of tubule cells required for normal function, which is subject to perturbation...
Plasma and urinary tanshinol from Salvia miltiorrhiza (Danshen), can be used as pharmacokinetic markers for cardiotonic pills, a cardiovascular herbal medicine. Drug Metab Dispos. 2008;36:1578–86. Article CAS PubMed Google Scholar Liu HF, Yang JL, Du FF, Gao XM, Ma XT, Huang YH, et al...
A randomized open-label clinical trial was performed with 49 ADPKD patients who were treated with 20 mg/d pravastatin or no treatment for 2 years[115]. There were no significant changes in the markers of kidney function or urinary protein excretion between the two groups. Triptolide Triptolide ...
of drug-induced (DI) CI are old age, childhood, brain damage, chronic diseases, and genetic factors, along with the presence of early CI in the patient, polypharmacy, dose and duration of drug use, acute infectious diseases, metabolic disorders, dehydration, acute urinary retention, and others...
Symptoms of PBC are edema, itching, elevated cholesterol, malabsorption of fat, liver cancer, gallstones, urinary tract infections (UTIs), and hypothyroidism. Treatments include ursodeoxycholic acid (UDCA); colchicine (Colcrys); and immunosuppressive medications, such as corticosteroids; obeticholic acid ...