Experimental study and thermodynamic modeling of Esomeprazole (proton-pump inhibitor drug for stomach acid reduction) solubility in supercritical carbon dioxideSupercritical carbon dioxide (SC-CO2)Solubility measurementEsomeprazole (ESM)Empirical and thermodynamic modeling...
The CYP4 family has gained increasing attention for its potential to generate interesting metabolites and dispose of endogenous substrates in recent years. CYP4F11, together with CYP4F2, plays an important role in the synthesis of 20-hydroxyeicosatetraenoic acid (20-HETE) from arachidonic acid, ...
The invention involves the formation of a prodrug from a fatty acid carrier and a neuroactive drug. The prodrug is stable in the environment of both the stomach and the bloodstream and may be delivered by ingestion. The prodrug passes readily through the blood brain barrier. Once in the centra...
(12岁以下儿童:咨询医生)可知,胃灼热超过3个月、不明原因的体重减轻和12岁以下儿童服用该药前需咨询医生,根据Uses一栏中的Itpreventsheartburnassociatedwithacidindigestionandsourstomachbroughtonbyeatingordrinkingcertainfoodsanddrinks.(它可以防止因食用或饮用某些食物和饮料而引起的与酸性消化不良和胃酸有关的胃灼热)...
The invention relates to a tablet for extended release of a drug in the stomach, comprising granules of said drug in a hydrophilic matrix, said granules being coated with a coating comprising a source of a carbon dioxide and said coating granules being blended with an agent inducing the release...
Acid suppressants such as histamine-2 receptor antagonists (H2RAs) and proton pump inhibitors (PPIs) are effective in preventing gastrointestinal (GI) bleeding in nonsteroidal anti-inflammatory drugs (NSAIDs) users. Despite widespread acid suppressant use, there remain concerns about several potential...
Peptic ulceration results from an imbalance between gastric acid/pepsin secretion and the ability of the mucosa of the upper gastrointestinal tract to withstand peptic digestion. Excessive secretion can be incriminated in many patients with duodenal ulce
Since the introduction of insulin almost a century ago, more than 80 peptide drugs have reached the market for a wide range of diseases, including diabetes, cancer, osteoporosis, multiple sclerosis, HIV infection and chronic pain. In this Perspective, we summarize key trends in peptide drug disco...
Design, Development and Evaluation of Oral Sustained Release In-Situ Floating Gel as A Carrier for Stomach Specific Delivery of Anti Ulcer Drug Gastroretentive drug delivery is one of the targeted strategy for prolonging gastric residence time, in management of peptic ulcer along with optimizing si....
(β-l-malic acid) (PMLA) nanoplatform againstTNBC[78]. Thenanoconjugate(P/AON/2C5/TfR) contains PMLA as the backbone, anti-tumor nucleosome-specific 2C5 antibody as a targeting agent, anti-mouse transferrin receptor (TfR) antibody as atumor vasculaturetargeting agent for drug delivery t...