FDA Commissioner David A. Kessler, M.D.; The cause of BPH unknown; What and where the prostate is located; Controlled clinical trials involving 1,645 participants for one year; Results; Merck and...
Fda Approves Ferring's Degarelix For Prostate Cancer The FDA has approved Ferring Pharmaceuticals' degarelix, which the agency says is the first new prostate cancer drug in several years, and the European Medicines Agency (EMEA) may be next to authorize it. Degarelix will be used to treat .....
Results: NDRG3 protein was expressed in two prostate cell lines (PC3, DU145) and a immortalized prostatic stromal cell lines (WPMY-1); exogenous expression of NDRG3 remarkably increased growth rate of PC3 cell line; NDRG3 expression inhibited mevastatin originated apoptosis. Conclusion: NDRG3...
Moreover, to handle the class imbalance problem, our proposed model used SMOTE to generate artificial examples for the minority class. However, during the cross-validation process, the test dataset also contains the artificial examples generated by SMOTE, which may cause the current reported ...
Another problem with the field of antiviral therapy is that the cost and incentive for developing, testing, and approving novel antivirals is often prohibitive. Simply put, the process of new drug development is financially unattractive, burdensome, and long. This can be addressed through drug rep...
The approaches were applied to the repurposing of existing drugs against ACK1, a novel cancer target significantly overexpressed in breast and prostate cancers during their progression. Upon screening of 1,447 marketed drugs, a final set of 10 hits were selected for experimental testing. Among them...
Similarly, another study was able to administer curcumin, a drug used for prostate cancer that is usually administered orally with low bioavailability, through NBs to prostate cancer cells and, similarly, found cytotoxic effects specific to the prostate cancer cells [15]. Overall, a variety of ...
Drug-condition interaction. This is when you have a health problem that makes it risky for you to take certain meds. For example, if you have a condition likehigh blood pressure, taking adecongestantfor acoldcould drive up yourblood pressureeven more. ...
The complex problem of drug resistance is discussed with respect to host toxicity, to tumor characteristics (kinetic resistance, heterogeneity of cell subpopulations, hypoxia, mutation and gene amplification), and to the medication itself (pharmacokinetic and pharmacodynamic resistance: cell membrane, intrac...
In the drug discovery scope, databases are in the greatest level of importance given that they are the basis for drug repositioning methods. Hence, it is necessary that they are designed in a proper manner and included capabilities which help researchers to achieve better results. Fig. 1 represe...