Possible importance for the treatment of unstable angina. Background The three major classes of antianginal drug all inhibit platelet aggregation at high concentrations in vitro, but detecting clinically relevant ... CJ Knight,M Panesar,DJ Wilson,... - 《Circulation》 被引量: 82发表: 1997年 ...
This was opposed to when investigating only significant associations where statins ranked 2 and 4 with high effect sizes (Supplementary Figs. 22 and 23). This observation may indicate that statins had fewer strong effects, whereas, for instance, both metformin and omeprazole with the highest ...
Center for Drug Evaluation and ResearchFood and Drug Administration. FDA drug safety communication: abnormal heart rhythms associated with high doses of ... CFDE And - Center for Drug Evaluation and Research 被引量: 107发表: 0年 How Often Are Drugs Made Available Under the Food and Drug Admi...
Why does a drug with a well-response for one patient, but not for the next, or in some cases, lead to serious adverse drug reactions (ADRs), namely individual variability in drug response (IVDR)? The answers are complicated and multi-faceted. First of all, therapeutic response rates of d...
These findings highlight the need for heightened clinical surveillance of PWID for chronic inflammatory diseases, particularly those with a history of HCV infection.Hearps, Anna C.Vootukuru, NikilEbrahimnezhaddarzi, SalimehHarney, Brendan L.
The potential impact of enhanced diagnostic techniques for tuberculosis driven by HIV: a mathematical model. To explore the potential impact of enhanced tuberculosis (TB) diagnostic techniques as a TB control strategy in an adult population with high HIV prevalenc... DW Dowdy,RE Chaisson,LH Moulto...
The survey results demonstrate high-risk sexual behaviors with multiple partners of both genders; 82% of the sample had primary and non-primary male partners, 20% had non-primary female partners, and 15% exchanged money or drugs for sex. Condom use was inconsistent and infrequent for all ...
In the treatment of infections with a high mortality rate such as pneumonia caused by XDR A. baumannii, combining tigecycline with colistin during the first 48h and continuing treatment with one of these agents seems a rational approach. 展开 关键词: XDR Acinetobacter baumannii Colistin Tigecycline...
high level of evidence, but are standardized on populations, less individualized and typically static, often focused only on just one disease entity. Data-driven approaches provide recommendations on an individualized level but require large amounts of empiric high quality data for reliable models and...
Identifying genetic drivers of chronic diseases is necessary for drug discovery. Here, we develop a machine learning-assisted genetic priority score, which we call ML-GPS, that incorporates genetic associations with predicted disease phenotypes to enhanc