PRENATAL drug exposureFETUSCORD bloodAMNIOTIC liquidCONVENIENCE sampling (Statistics)PREGNANCYPrescription drug use is prevalent during pregnancy, yet there is limited knowledge about maternal-fetal safety and efficacy of this drug use because pregnant individuals have historically been ex...
cocaine or methamphetamine) during pregnancy. Apart from the negative impacts on the developing brain, many babies born from drug-abusing mothers present with imbalanced blood glucose levels, which statistically affects more female newborns.
Murphy and her colleagues examined the effect of OHPC exposure on thecancer riskamong adult offspring of mothers who used OHPC during the pregnancy with them versus offspring whose mothers did not. All mothers were participants in the Child Health and Development Studies, a group who received prena...
European countries such as the UK, and Australia) beginning in the 1940s to prevent miscarriage. It was not until 1971, however, that a landmark article published in the New England Journal of Medicine linked in utero DES exposure to
37. European Medicines Agency / Committee for Medicinal Products for Human Use. Guideline on The Exposure to Medicinal Products During Pregnancy: Need to Post-Authorisation Data. Current as of May 2006. Accessed 23 February 2023. https://www....
pregnancy drug exposure registries evaluating drug safety in pregnancyCenter for Drug Evaluation and Research (CDERMedications are commonly used during pregnancy, either inadvertently in an unrecognized pregnancy or intentionally for treatment of acute or chronic conditions. However, randomized clinical trials...
that a landmark article published in the New England Journal of Medicine linked in utero DES exposure to a rare type of vaginal tumor in women whose mothers had received the drug during their pregnancy. This finding led US and European regulators to recommended that DES no longer be prescribed...
Purpose The results of observational cohort studies on drug effects on pregnancy outcome may depend among others on suitable comparison cohorts. The aim of this investigation was to compare two distinct definitions of maternal exposure status for comparison cohorts. Methods We performed an observational ...
First trimester exposure to paroxetine and risk of cardiac malformations in infants: the importance of dosage 2) be covered by the RAMQ drug plan 12 months before and during pregnancy; 3) be using only one type of antidepressant during the first trimester; an... A Bérard,E Ramos,E Rey,....
average of 1.81 prescriptions in first trimester and 3.57 pre-scriptions in the whole gestational period, Compared with the literature,overall drug use decreased during pregnancy in this study.However,there was still substantial exposure to drugs,including drugs that are contraindi-cated in pregnancy...