pregnancyfetal drug exposureprenatal testingpharmacokineticsPrescription drug use is prevalent during pregnancy, yet there is limited knowledge about maternal-fetal safety and efficacy of this drug use because pregnant individuals have historically been excluded from clinical trials. Underrepresentation has ...
The goal of these registries is to gather information on the safety of exposure to these vaccines during pregnancy, as current human data is limited. Sanofi Inc. encourages the reporting of all occurrences of vaccination during pregnancy and any temporally related adverse events to the appropriate ...
pregnancy drug exposure registries evaluating drug safety in pregnancyCenter for Drug Evaluation and Research (CDERMedications are commonly used during pregnancy, either inadvertently in an unrecognized pregnancy or intentionally for treatment of acute or chronic conditions. However, randomized clinical trials...
that a landmark article published in the New England Journal of Medicine linked in utero DES exposure to a rare type of vaginal tumor in women whose mothers had received the drug during their pregnancy. This finding led US and European regulators to...
Merck Pregnancy Registries - useful information about the outcomes of pregnancies following use of a drug during gestation. Pregnancy Registries are prospective active data collections systems which can facilitate the early detection of teratogenicity a
where babies were born with a range of major congenital malformations resulting from their mother’s use of thalidomide in the first trimester of pregnancy, more attention has been given to the potential for fetal exposure. Since then, several different approaches and types of data source have bee...
37. European Medicines Agency / Committee for Medicinal Products for Human Use. Guideline on The Exposure to Medicinal Products During Pregnancy: Need to Post-Authorisation Data. Current as of May 2006. Accessed 23 February 2023. https://www....
The use of cocaine during pregnancy can have a variety of effects on babies, and it appears that the effects worsen when exposure is higher. When used early in pregnancy, cocaine is thought to affect the structure and function of the brain, which may predispose children to developmental, behav...
5. Infection-Mediated Modulation of Drug Transporters in Pregnancy; Implications for Fetal Drug Exposure. [D] . Petrovic, Vanja. 2015 机译:妊娠中药物转运蛋白的感染介导调节;对胎儿药物暴露的影响。 6. Maternal cigarette smoking during pregnancy and infant ponderal index at birth in the Swedish Me...
cocaine or methamphetamine) during pregnancy. Apart from the negative impacts on the developing brain, many babies born from drug-abusing mothers present with imbalanced blood glucose levels, which statistically affects more female newborns.