药物相互作用(Drug-drug interaction, DDI)指的是同时使用多种药物时,药物之间产生的药代动力学和药效动力学改变,可
Other types of drug action Certain drugs act without engaging in any direct interaction with the components of the cell. An example ismannitol, an inert polysaccharide that acts purely by its osmotic effect. This drug increasesurineproduction markedly because it interferes with water reabsorption by ...
Drug–drug interactions are of two types: • both drugs act on the same target, withoutpharmacokineticinterferences (pharmacodynamic interaction); • the co-administration of two drugs produces changes in their disposition (absorption, distribution, metabolism, and excretion) and, possibly, also ...
Drug Interaction Facts, Drug-Reax, Lexi-Interact, Pharmavista, Stockley’s Drug Interactions, The Medical Letter and Vidal ,常用于处方 (用 药医嘱)的检查,以发现最具临床相关性的DDI Drug-Reax (Micromedex®) Lexi-Interact Pharmavista 信息系统识别DDI 此外,一些其它的数据库也列出了已知的DDI,包括:Da...
Minor Interaction is unlikely, minor, or nonsignificantWhat are drug interactions? 4 Types A drug interaction can be defined as an interaction between a drug and another substance that prevents the drug from performing as expected. There are 4 types of drug interactions include: interactions of dr...
相关概念相互作用对(interactionpair)能够引起药物效应变化的两个药物目标药物(objectdrug,orindexdrug)在联合用药中,药效发生变化的药物相互作用药物,促发药物(interactiondrug,orprecipitatingdrug)在联合用药中,引起其他药物发生变化的药物 2药物相互作用的研究对象 药物在体外和药物在体内的相互作用药物...
药物相互作用(DDI)指一种药物的效应受到另一种药物、食物或者环境的影响而发生改变的现象。在临床工作中,通常指一种药物的药代动力学或药效动力学被另一种药物改变。因药物相互作用而被召回的上市新药,已经有多个先例(如2001年因DDI引起横纹肌溶解的降脂药西立伐他汀、2000年出现尖端扭转型室速的胃药西沙比利等),...
关键词:drug-drug interaction, 图神经网络GNN 一、相关概念 1.1 DDI prediction Given a set of triplets consisting of two drugs D and interaction types R , the DDI prediction can be formulated as a function f:D×R×D→[0,1] , where 1 indicates that a triplet (Di,R,Dj) of ...
相关概念相互作用对(interactionpair)能够引起药物效应变化的两个药物目标药物(objectdrug,orindexdrug)在联合用药中,药效发生变化的药物相互作用药物,促发药物(interactiondrug,orprecipitatingdrug)在联合用药中,引起其他药物发生变化的药物 2药物相互作用的研究对象 药物在体外和药物在体内的相互作用药物...
药物相互作用(DDI)指一种药物的效应受到另一种药物、食物或者环境的影响而发生改变的现象。在临床工作中,通常指一种药物的药代动力学或药效动力学被另一种药物改变。因药物相互作用而被召回的上市新药,已经有多个先例(如2001年因DDI引起横纹肌溶解的降脂药西立伐他汀、2000年出现尖端扭转型室速的胃药西沙比利等),...