Drug-drug-interactionPaxlovid™PhenytoinTacrolimus toxicitynirmatrelvir/ritonavirIntroduction:The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or COVID-19) pandemic has had a significant impact on communities and health systems. The Federal Drug Administration (FDA) authorized Pfizer...
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Nirmatrelvir (coadministered with ritonavir as PAXLOVIDTM) reduces the risk of COVID-19-related hospitalizations and all-cause death in individuals with mi
Paxlovid™nirmatrelvir/ritonavirTacrolimus toxicityDrug-drug-interactionPhenytoinThis case highlights the strong and important drug–drug interaction between tacrolimus and nirmatrelvir/ritonavir leading to toxic levels of tacrolimus. It also demonstrates the utility and effectiveness of phenytoin as a "...
doi:10.1007/s13181-023-00936-4Luciana Mello de OliveiraTatiane da Silva Dal PizzolSpringer USJournal of Medical Toxicology
Drug-drug interactionTacrolimusNirmatrelvir/ritonavirdoi:10.1007/s13181-023-00940-8Morganne,SindelarDaniel,McCabeElisabeth,CarrollSpringer USJournal of medical toxicology