CRISPR-based drugs can theoretically manipulate any genetic target. In practice, however, these drugs must enter the desired cell without eliciting an unwanted immune response, so a delivery system is often required. Here, we review drug delivery systems
Liang S, Meroueh SO, Wang G, Qiu C, Zhou Y (May 2009).“Consensus scoring for enriching near-native structures from protein-protein docking decoys”.Proteins75(2): 397–403.doi:10.1002/prot.22252.PMC2656599.PMID18831053. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2656599/. Oda A, Tsuc...
Prospective clinical sample collection took place in two locations in Ghana, one urban (LEKMA Hospital, Accra, on the coast) with perennial malaria transmission and one rural (three sites in and around Navrongo, in the Upper East Region), where malaria transmission is highly seasonal (Extended D...
The best way to dispose of most types of unused or expired medicines (both prescription and over the counter) is to immediately drop off the medicine at a drug take-back site, location, or program. Pharmacies, firehouses, or police departments will often “take back” unused medic...
Such remote locations could thereby summon an ambulance or other trained caregiver to respond to the alarm alert. FIG. 18 details the user interface system of a preferred embodiment of the invention. This system enables the physician to safely and efficaciously deliver one or more of sedation, ...
(PSA) and TMPRSS2. At the promoter, the AR is able to recruit members of the basal transcription machinery [such as TATA-box-binding protein (TBP) and transcription factor IIF (TFIIF)] in addition to other coregulators such as members of the p160 family of coactivators and cAMP-response...
The failure of many clinical trials of the pioneering matrix metalloproteinase (MMP) inhibitors in oncology owing to lack of efficacy and side effects, such as musculoskeletal toxicity, reduced enthusiasm for further development of the drug class. Vanden
(PSA) and TMPRSS2. At the promoter, the AR is able to recruit members of the basal transcription machinery [such as TATA-box-binding protein (TBP) and transcription factor IIF (TFIIF)] in addition to other coregulators such as members of the p160 family of coactivators and cAMP-response...
Babu and co-workers used the complex between nepafenac (NF), a water-insoluble nonsteroidal anti-inflammatory drug, and HP- β-CD to formulate an ion-activated in situ gel system using sodium alginate and protanal PH 1033 in order to enhance the residence time and reduce repeat eye drop ...
a 2 ns NPT simulation at 298 K with a Berendsen barostat to bring the density and the pressure of the simulation box to near-equilibrium conditions at 1 bar; a 2 ns NPT simulation at 298 K with a Parrinello–Rahman barostat to ensure that sampling is adequate in the isothermal–isobaric...