You try and box it, and park it off, Unconsciously, in your own head and so there's that. And then functionally, the service isn't doing anything about it…I feel very strongly about it, I have been trying to ask people for the last two years that we as doctors, and nurses within...
Liang S, Meroueh SO, Wang G, Qiu C, Zhou Y (May 2009).“Consensus scoring for enriching near-native structures from protein-protein docking decoys”.Proteins75(2): 397–403.doi:10.1002/prot.22252.PMC2656599.PMID18831053. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2656599/. Oda A, Tsuc...
CRISPR-based drugs can theoretically manipulate any genetic target. In practice, however, these drugs must enter the desired cell without eliciting an unwanted immune response, so a delivery system is often required. Here, we review drug delivery systems
ArticlePubMedPubMed CentralGoogle Scholar Yarnall, M. T. N. et al. Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases.Nat. Biotechnol.41, 500–512 (2022). ArticlePubMed Durrant, M. G. et al. Systematic discovery of recombin...
In this paper we propose PIICM, a probabilistic framework for dose–response prediction in high-throughput drug combination datasets. PIICM utilizes a permutation invariant version of the intrinsic co-regionalization model for multi-output Gaussian proce
Prospective clinical sample collection took place in two locations in Ghana, one urban (LEKMA Hospital, Accra, on the coast) with perennial malaria transmission and one rural (three sites in and around Navrongo, in the Upper East Region), where malaria transmission is highly seasonal (Extended ...
VCP is present in different subcellular locations [132,133,134]. VCP’s functions are required in the nucleus and cytoplasm, and the ATPase shuttles between both compartments. A nuclear localization sequence (NLS) in the N-terminal domain of VCP (amino acid residues 60 to 66) promotes nuclear...
Androgens and androgen receptors (AR) play a pivotal role in expression of the male phenotype. Several diseases, such as androgen insensitivity syndrome (AIS) and prostate cancer, are associated with alterations in AR functions. Indeed, androgen blockade
(PSA) and TMPRSS2. At the promoter, the AR is able to recruit members of the basal transcription machinery [such as TATA-box-binding protein (TBP) and transcription factor IIF (TFIIF)] in addition to other coregulators such as members of the p160 family of coactivators and cAMP-response...
A, Bulk RNA-seq analysis on PC specimen (n = 20) using a curated panel of immune checkpoint and “don’t eat me” gene. Unsupervised hierarchical clustering was performed on the normalized RNA expression data of indicated genes. B, Box plot analysis showed immune checkpoint and “don’t ea...