Fungal infections pose a serious health threat, affecting more than one billion people and causing approximately 1.5 million deaths each year1,2. The problem is growing due to insufficient diagnostic and therapeutic options3,4, increasing numbers of susceptible patients1,5, the expansion of pathogens...
To identify genes under recent selection inCandidapathogens, we retrieved all publicly available short-read whole-genome sequencing data for pure isolates (that is, clinical and environmental) of six major species and identified four variant types: single-nucleotide polymorphisms (SNPs), small insertions...
There are thousands more teenagers like Nathan living in the UK. Prohibitionist drug laws, vast inequalities, consumer capitalism, and the relatively new phenomenon of online social media are combining to generate a noxious trap enveloping many of these young people. One of the most obvious and fe...
Tramadol Drug Market Driving FactorsThe major factor driving the growth of the market is the increasing prevalence of pain and pain disorders globally.For instance, according to Centers for Disease Control and Prevention (CDC), in the U.S. adults, about 58.5 million people had doctor-diagnosed ...
driving mutations. By using this strategy, we can uncover potential effective drug combinations on a pan-cancer scale. Predicted synergies are provided and have been validated in glioblastoma, breast cancer, melanoma and leukemia mouse-models, resulting in therapeutic synergy in 75% of the tested ...
Why do we think that legalising drugs would automatically lead to people drug-driving and arriving to work stoned? Why do we assume that floodgates will be opened, and all lawfulness and decency will be swept away? Speaking out Although I’ve written about drugs through mytwocomics, this is...
[4]Wieduwilt MJ, Moasser MM. The epidermal growth factor receptor family: biology driving targeted therapeutics.Cell Mol. Life Sci.2008, 65, 1566–1584.Search in Google Scholar [5]Normanno N, De Luca A, Maiello MR, Campiglio M, Napolitano M, Mancino M, Carotenuto A, Viglietto G, ...
[4]Wieduwilt MJ, Moasser MM. The epidermal growth factor receptor family: biology driving targeted therapeutics.Cell Mol. Life Sci.2008, 65, 1566–1584.Suche in Google Scholar [5]Normanno N, De Luca A, Maiello MR, Campiglio M, Napolitano M, Mancino M, Carotenuto A, Viglietto G, Me...
thus driving epistatic patterns observed in cancer sequencing studies43,44. Theoretically, if epistasis is driven by the selective pressure of leukemia fitness, then there might be correlations between broad binary epistatic trends and features of disease presentation and patient outcomes. To better unde...
been slow. This approach is complicated by the reality that patients often harbour multiple mutations, and in many cases, the precise functional significance and interaction of these mutations in driving leukaemia and drug responsiveness/resistance remains unknown. Given that signalling pathways driving le...