An example for drug-disease interaction: Cardiac side effects related to rivastigmine in a patient with Lewy Body DementiaDelirium is a complex syndrome defined as an acute, fluctuating syndrome of altered attention, awareness, and cognition. Delirium is common in the elderly, but unfortunately ...
In the third type of mechanism, which is peculiar tosteroid hormonesand related drugs, the steroid binds to a receptor that consists primarily of nuclear proteins. Because this interaction occurs inside the cell, agonists for this receptor must be able to cross the cell membrane. The drug-recept...
The effect of drug on a person may be different than expected because that drug interacts with another drug the person is taking (drug-drug interaction), f... Tsung O Cheng - 《International Journal of Cardiology》 被引量: 120发表: 2011年 Drug-Food Interactions in Hospitalised Patients Drug...
the colon, stimulating CD8+T cells and Th1 cells, thus enhancing the infiltration of interferon (IFN)-γ-producing γδT cells into tumors.238The interaction between IVDR of CTX and the microbiota is complex, as CTX affects the intestinal barrier integrity, resulting in the translocation of path...
The risk of toxicity is increased in these patients as well as in patients with cardiovascular disease, dehydration, or hypokalemia. The most common drug–drug interactions involving lithium are pharmacokinetic. Because lithium has a low therapeutic index, such interactions are likely to be clinically...
When that happens, it's called a drug interaction. It could make your medication stop working, become less effective, or too strong. It could also trigger side effects. The more you learn about drug interactions, the better you'll be able to avoid them. Here's what you need to know. ...
Cancer, a complex and multifactorial disease, presents a significant challenge to global health. Despite significant advances in surgical, radiotherapeutic and immunological approaches, which have improved cancer treatment outcomes, drug therapy continue
govrephetiodrug-repurposingdiseaseclinical-trialsdrugindications UpdatedJun 17, 2016 Jupyter Notebook TIP: Tri-graph Interaction Propagation model for Polypharmacy Side Effect Prediction (GRL@NeurIPS, 2019) deep-learningpytorchproteinknowledge-graphdrugtensor-factorizationlink-predictionbiographygcnside-effects...
GSL-DTI Graph Structure Learning Network for Drug-Target Interaction Prediction.pdf 1.2M · 百度网盘 摘要 动机:药物-靶标相互作用预测是预测药物分子与其靶蛋白之间是否存在相互作用的一个重要研究领域。它通过促进潜在候选药物的识别并加快整个过程,在药物发现和开发中发挥着关键作用。鉴于传统药物发现方法耗时、昂...
(Müller and Fromm, 2011). Countless studies are going on to assess the role of various drugs on transporter-mediated efflux or uptake of another drug (König et al., 2013). Some of the important transporters and examples of transporter-mediated effects of drug–drug interaction on PK ...