Intraocular retinoblastoma treatment has changed radically over the last decade, leading to a notable improvement in ocular survival. However, eyes that re
Chapter 1-Drug discovery and development: An overview of modern methods and principles Pages 1-41 Purchase View chapter Select Chapter 2 - The drug discovery process: From ancient times to the present day Book chapterNo access Chapter 2-The drug discovery process: From ancient times to the pres...
A system dynamics structure to characterize the link between technology and critical management decisions in the drug discovery process (DDP) is needed. The DDP includes many interacting feedback loops that impact decisions executed in early stages and that influence performance in later development stag...
Discovery of selective low molecular weight interleukin-36 receptor antagonists by encoded library technologies IL-36 receptor is crucial for host defense and tissue repair. Here, the authors describe identification and characterization of low molecular weight inhibitors of the IL-36 receptor using encoded...
N. Current status and future prospects for enabling chemistry technology in the drug discovery process. F1000Res 5, 2426 (2016). Article PubMed PubMed Central Google Scholar Scannell, J. W., Blanckley, A., Boldon, H. & Warrington, B. Diagnosing the decline in pharmaceutical R&D efficiency...
In current drug discovery, the primary focus is on activity against the protein (or the biological process to be restored), with other aspects of compound action being relegated to secondary importance (aspects that can be ‘addressed later’). Conceptually, this still applies to all approaches ...
These profiles can be mined for relevant patterns, revealing unexpected biological activity that is useful for many steps in the drug discovery process. Such applications include identifying disease-associated screenable phenotypes, understanding disease mechanisms and predicting a drug’s activity, ...
Drug Discovery Medicilon's drug discovery services include chemistry (synthetic chemistry, medicinal chemistry) and biology. Our chemistry team can deliver complex activities such as custom synthesis of compounds, compound library construction, SAR analysis and screening, compound structure determination and ...
dramatically accelerate the drug-discovery process. We believe that increasing collaboration between academic and industrial chemists is crucial to address the challenges outlined here. Access options Access Nature and 54 other Nature Portfolio journals...
Since lipid synthesis is regarded as an essential process, especially during tachyzoite intracellular development, for membrane genesis and lipid homeostasis and signaling, its inhibition is of great interest in anti-T. gondii drug discovery [83]. 4.2.1. The FAS II Enzyme Enoyl-Acetyl Carrier ...