This chapter presents an overview of the drug discovery process from the laboratory bench through postmarketing approval. A brief history of drug discovery through the ages is included to provide perspective on the current situation and anticipated changes in the near future. Aspects of drug ...
Overview of Drug Developmentthe Regulatory Process:药物发展的监管过程概述.ppt,Overview of Drug Development: the Regulatory Process Roger D. Nolan, PhD Director, Project Operations Calvert Research Institute November, 2006 Background: The New Drug Develo
Drug repositioning is a drug-discovery strategy that relies on a priori knowledge to recommend an existing drug for a new indication based on evidence from clinical data (e.g., off-label prescriptions) or biological experiments (e.g., gene expression profiling after drug perturbations) (111,112...
An Overview of Drug Research and Discovery Processdoi:10.36648/2321-547X.21.9.51iMedPubAnusharada
These profiles can be mined for relevant patterns, revealing unexpected biological activity that is useful for many steps in the drug discovery process. Such applications include identifying disease-associated screenable phenotypes, understanding disease mechanisms and predicting a drug’s activity, ...
Authentic 3D cell culture models are enhancing the drug discovery process by modelingin vivoconditions and microenvironments far more precisely, yielding results with better clinical outcomes. Research methods and models will need to consider that the response to drugs varies not only with the tumor ...
We outline our opinions and experiences on key stages in the small-molecule drug discovery process: target selection, medicinal chemistry, antiviral assays, animal efficacy and attempts to pre-empt resistance. We propose strategies that could accelerate future efforts and argue that a key bottleneck ...
It provides students, new industrial scientists, and academics with a basic understanding of the drug discovery and development process. The fully updated text provides an excellent overview of the process and includes chapters on important drug targets by class, in vitro screening methods, medicinal ...
Introduction to the volume and overview of computer assisted drug design in the drug discovery process. In Comprehensive Medicinal Chemistry II; Taylor, J.B., Triggle, D.J., Eds.; Elsevier: Amsterdam, The Netherlands, 2007; pp. 1–11. [Google Scholar] Swaminathan, K.; Meller, J. ...
The adoption of “artificial intelligence (AI) in drug discovery”, where AI is used in the process of pharmaceutical research and development, is progressing. By using the ability to process large amounts of data, which is a characteristic of AI, and achieving advanced data analysis and infere...