Drug repositioning is a drug-discovery strategy that relies on a priori knowledge to recommend an existing drug for a new indication based on evidence from clinical data (e.g., off-label prescriptions) or biological experiments (e.g., gene expression profiling after drug perturbations) (111,112...
drug discovery in manifold ways. This chapter presents an overview of the drug discovery process from the laboratory bench through postmarketing approval. A brief history of drug discovery through the ages is included to provide perspective on the current situation and anticipated changes in the near...
An Overview of Drug Research and Discovery Processdoi:10.36648/2321-547X.21.9.51iMedPubAnusharada
Nature Reviews Drug Discovery volume 3, pages 673–683 (2004)Cite this article 28k Accesses 89 Altmetric Metrics details Key Points The process of finding new uses outside the scope of the original medical indication for existing drugs is known as drug repositioning. Repositioning existing drugs...
The analytical method lifecycle is a continuous development process that builds on the understanding of the capabilities of each analytical method used throughout the discovery, pre-clinical and clinical development of a new drug candidate. ...
Later on, we presented an overview on the congregation of AI and conventional chemistry in the improvement of the drug discovery process and the application of AI in the improvement of the traditional drug discovery process. Afterward, we discuss the numerous AI applications throughout the drug ...
These profiles can be mined for relevant patterns, revealing unexpected biological activity that is useful for many steps in the drug discovery process. Such applications include identifying disease-associated screenable phenotypes, understanding disease mechanisms and predicting a drug’s activity, ...
Effective XAI can also help scientists in navigating the scientific process (Goebel et al.2018), enabling people to fine-tune their understanding and opinions on the process under inquiry (Chander et al.2018). We hope to provide an overview of recent XAI drug discovery research in this section...
Since lipid synthesis is regarded as an essential process, especially during tachyzoite intracellular development, for membrane genesis and lipid homeostasis and signaling, its inhibition is of great interest in anti-T. gondii drug discovery [83]. 4.2.1. The FAS II Enzyme Enoyl-Acetyl Carrier ...
15.1Overview Drug developmentis the process of bringing a new drug to the market and consists of multiple stages starting with the discovery of the lead compound, followed by preclinical research (conducted in microorganisms and animals),clinical trials(in humans), and regulatory approval to market ...