Drug Interaction CategoriesDescriptions Contraindicated Never use this combination of drugs because of the high risk of dangerous interaction Serious Potential for serious interaction; regular monitoring by your doctor is required or alternate medication may be needed Significant Potential for significant intera...
References 80 and 81 are recent descriptions of cases of PML with natalizumab. Article CAS PubMed Google Scholar Yousry, T. A. et al. Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy. N. Engl. J. Med. 354, 924–933 (2006). Article CAS PubMed ...
A European Union guideline now recommends use of qualitative descriptions for five bands of risk, ranging from very rare (affecting 10%). We did four studies of more than 750 people, whom we asked to estimate the probability of having a side-effect on the basis of qualitative and ...
A brief overview of drug repositioning with descriptions of successful repositioning efforts, including thalidomide, Viagra, Botox, Mifepristone, Celebrex and Vioxx. Google Scholar Thor, K. B. Methods of using rapid-onset selective serotonin reuptake inhibitors for treating sexual dysfunction. WO Patent...
Brief yet insightful descriptions paired with each documentary give you a glimpse of what lies beneath the title, whilst capturing the essence of the documentary. What makes this platform truly unique is the power it gives to the viewers. Your votes have the strength to shift the rankings, ...
We demonstrated that our system can be trained to identify sentences with complex side effect descriptions that can be submitted to a human expert for further abstraction. CONCLUSION: Our system was able to extract most physician-asserted drug side effects. It can be used in either an automated ...
Comparisons between molecules are made based on 2D topological structural considerations, based on 3D surface characteristics, and based on English descriptions of clinical effects. Similarity computations within each modality were transformed into probability scores. Given a new molecule along with asetof...
HPO contains phenotypic descriptions of 7529 diseases, the majority of which were derived from the Online Mendelian Inheritance in Man (OMIM) [30]. Studies of phenotypic abnormalities in HPO have advanced our understanding of the genetic bases of diseases [31], [32], [33]. In a recent study...
(RDKit) package in python. We used an RDKit-specific fingerprint that is inspired by public descriptions of the well-known Daylight fingerprint. The RDKit-specific algorithm is based on hashing molecular subgraphs. A detailed explanation of how this is computed can be found in the RDKit book...
(1) Searching for drug candidate descriptions by utilizing specific tags (e.g., "Drug:" for ClinicalTrials.gov) and (2) searching for drug names, synonyms, etc. based on DrugBank. Second, clinical trials for the rare and intractable diseases were selected by searching for the 787 disease ...