This review focuses on design of two supramolecular nanosheets. One is tubulin protein-based supramolecular nanosheet for applications to GTP-responsive drug delivery system. The other is phospholipid-based supramolecular nanosheets and their applications in blood-administrated drug delivery systems....
Designing therapeutics is a process with many challenges. Even if the first hurdle — designing a drug that modulates the action of a particular biological target in vitro — is overcome, selective delivery to that target in vivo presents a major barrier
Peptide-based supramolecular hydrogels have shown great promise as drug delivery systems (DDSs) because of their excellent biocompatibility, biodegradability, biological function, synthetic feasibility, and responsiveness to external stimuli. Self-assembling peptide molecules are able rationally designed into spe...
Effective drug delivery is important in the treatment of various biomedical conditions, ranging from autoimmune disorders to cancer and bacterial infections. Nanostructured systems can help to overcome challenges to efficient drug delivery such as poor d
Cell therapies, such as immune cell and stem cell therapies, are being preclinically and clinically explored for the treatment of various diseases, but are often limited by low efficacy and safety concerns. Drug delivery systems at the nanoscale, microscale and macroscale can be designed to improve...
Similar approaches have been used to design hydrogels based on dextran [75], poly(vinyl alcohol) [76] and poly(aldehyde guluronate; an oxidized alginic acid derivative) [77]. The latter has been used as an injectable matrix for the effective delivery of osteoblasts and growth factors [77]. ...
by tissues, thus stimulating tissue regeneration [113]. Nanocarriers can protect drugs and release them slowly, improving the blood circulation time of drugs in the body. Additionally, the response ability of the nanodrug delivery system can be adjusted to various stimuli, such as magnetic fields,...
Design of supramolecular nanosheets for drug delivery applications Two specific concepts have emerged in the field of materials science over the last several decades: nanosheets and supramolecular polymers. Based on this background, supramolecular nanosheets, in which these two concepts are integrated, ....
By combining living cells with therapeutics, cell–drug conjugates can potentiate the functions of both components, particularly for applications in drug delivery and therapy. The conjugates can be designed to persist in the bloodstream, undergo chemotax
Polymeric drug delivery vehicles can be designed as nanoparticles that release the encapsulated drugs through surface or bulk erosion, diffusion, or swelling, followed by diffusion in a time or condition dependent manner. From: Urologic Oncology: Seminars and Original Investigations, 2008 ...