Classification of the polymer. 4.3.1 Natural Polymers In recent decades, natural polymers have become the prime choice for the development of drug delivery systems due to their highly compatible and biodegradable nature as compared with synthetic polymers (Tekade et al., 2017b). These polymers ...
Fungal infections, a leading cause of mortality among eukaryotic pathogens, pose a growing global health threat due to the rise of drug-resistant strains. New therapeutic strategies are urgently needed to combat this challenge. The PCA pathway for biosyn
drug efficacy and reduce drug-drug interactions.141Mobility of gut microbiota is not limited to movement within inter-individuals, but can also occur within intra-individuals due to factors such as spatial, transient, seasonal, hormonal, and nutritional changes or the presence of multiple drugs.159T...
Computer-generated signals of possible drug-related incidents were derived from automated data. Such signals included elevated drug levels, abnormal laboratory results, the use of medications considered to be antidotes, and diagnoses (International Classification of Diseases, Ninth Revision [ICD-9])13 ...
For some approved, commercial drugs, biomarkers are also pivotal to the design of companion diagnostics, an assay that detects a predictive biomarker, and is approved by clinical trials, thereby allowing classification of patients (tumors) into responders and non-responders, for the corresponding...
“Omics” approaches can be used for identification or classification of toxic compounds or to generate mechanistic understanding of cellular processes underlying adverse outcomes to those compounds. Therefore, “omics” technologies are very suited to enhance preclinical safety assessment of DILI [200]. ...
2). Fig. 2 Schematic diagram of the classification of norcantharidin targeted drug delivery systems Full size imagePassive targeted drug delivery systems Passive targeted drug delivery systems are drug delivery systems that passively enriche drugs in tumor tissue based on EPR effects at the tumor ...
Classification of the tumor microenvironment. Underlying mechanisms of repurposed drugs targeting the specialized tumor microenvironments (TMEs). The TME can be divided into seven specialized microenvironments: hypoxic niche, immune microenvironment, metabolic microenvironment, acidic niche, innervated niche, ...
H. A functional-phylogenetic system for the classification of transport proteins. J. Cell Biochem. Suppl. 32–33, 84–94 (1999). Article Google Scholar Krishnan, K., Campbell, S., Abdel-Rahman, F., Whaley, S. & Stone, W. L. Cancer chemoprevention drug targets. Curr. Drug Targets 4...
Poisoning is one of the leading causes of admission to the emergency department and intensive care unit. A large number of epidemiological changes have occurred over the last years such as the exponential growth of new synthetic psychoactive substances. Major progress has also been made in analytical...