DREAMwalk performs teleport operation while random walking by using semantic similarity as its guide (Fig.1a). The widely used Anatomical Therapeutic Chemical (ATC) classification and medical subject headings (MeSH) describe the semantic hierarchy of drugs and diseases, respectively (Supplementary Table1...
being supported, further (c)hazard identificationof pharmaceutical lead structures and metabolites, (d) multi-objective optimization of drug candidate series, (e) detailed mechanistic investigation ofadverse drug reactions, (f) risk classification of impurities, extractables and leachables and (g) human ...
Some notable drugs which have been definitively associated with this condition includes hydralazine, isoniazid, procainamide, methyldopa (withdrawn), quinidine, minocycline, and chlorpromazine [154,155]. In a study of seven patients taking hydralazine, six were positive for ANA. Five of the seven ...
Possible Classification of DILI with AIH Features, Based on Clinical Characteristics and Histology Clinical Characteristics Histology AIH with DILI Patients with known AIH; probably chance association Usual AIH histology Often advanced fibrosis Drug-induced AIH (e.g., anti–TNF-α, β-interferon)...
Hydralazine-induced lupus: no association with HLA-DR4. Lancet 2: 462, 1984 Budinsky RA, Roberts SM, Coast EA, Adams L, Hess EV. The formation of procainamide hydroxylamine by rat and human liver microsomes. Drug Metabolites and Disposition 15: 37–43, 1987 Burlingame RW, Rubin RL. ...
Food and Drug Administration; Controversy surrounding the use of racial and ethnic categories in medicine. 展开 关键词: Humans Isosorbide Dinitrate Hydralazine Drug Combinations Pharmacogenetics Continental Population Groups DOI: 10.1136/bmj.330.7499.1036 被引量: 44 ...
Hypertension—ambrisentan, bosentan, diazoxide, hydralazine, iloprost, minoxidil, sildenafil, sitaxentan, sodium nitroprusside, clonidine, methyldopa, moxonidine, guanethidine monosulphate, doxazosin, indoramin, prazosin, terazosin, phenoxybenzamine, phentolamine mesilate, ...
A single bead drug delivery system suitable for oral administration with multiply layered drug and polymer compartments can provide a two-step release of active agent to facilitate an immediate yet sustained drug delivery over a 24 hour period following
Nitrates are vasodilators (dilate the blood vessels) that are used to treat angina (chest pain caused by lack of oxygen to the heart muscle) and ease the symptoms of congestive heart failure (a chronic progressive condition that affects the pumping power
Classification and function of HMTs HMTs and its classification HMTs are a class of enzymes that catalyze the methyl groups of histone proteins. According to the amino acids catalyzed by this enzyme, HMTs are divided into two families: histone lysine methyltransferases (KMTs) and protein arginine...