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In RPDR, dementia incidence was defined by the presence of either one or several dementia diagnosis codes (expertly curated list of International Classification of Diseases (ICD) codes including: (a) ICD10 codes: 290.X, 294.X, and 331.X; (b) ICD9 codes: 780.93, G30.X, and G31.X ...
BCS classificationControlled-release dosage formIntestinal permeabilityRegioselective absorptionSegmental-dependent permeabilityThe purpose of this work was to study the challenges and prospects of regional-dependent absorption in a controlled-release scenario, through the oral biopharmaceutics of the sulfonylurea ...
Predicting Clearance Mechanism in Drug Discovery: Extended Clearance Classification System (ECCS) Manthena V. Varma1, Stefanus J. Steyn2, Charlotte Allerton1, and Ayman F. El-Kattan2,* 1Pfizer Global Research and Development, Pfizer Inc., Groton, Connecticut 06340. 2Pfizer Global Research ...
A solid self-nanoemulsifying drug-delivery system (solid SNEDDS) has been explored to improve the solubility and dissolution profile of glipizide. SNEDDS preconcentrate was systematically optimized using a circumscribed central composite design by varying Captex 355 (Oil), Solutol HS15 (Surfactant) and...
Voluntary action indicated means that inspectors have found violations of good clinical practice, but the nature and extent of those problems are not serious enough to require sanction. The most severe classification, official action indicated (OAI), is reserved for cases in which the inspection ...
Drugs in every major pharmacological category can impair both taste and smell function and do so more commonly than presently appreciated. Impairment usual
2Classification of HyperlipoproteinemiasLipid Elevations Type Lipoproteins elevated major minor I chylomicrons TG ↑→C IIa LDL C - IIb LDL, VLDL C TG III (rare) IDL C/TG - IV VLDL TG ↑→C V (rare) chylomicrons, VLDL TG ↑→C IDL = intermediate-density lipoprotein.Adolescent...
Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system Eur J Pharm Sci, 29 (2006), pp. 278-287 View PDFView articleView in ScopusGoogle Scholar ...
Keywords In vitro –in vivo correlation IVIVC Oral formulation Development Biopharmaceutics Classification System Dissolution 1. Introduction Worldwide, the pharmaceutical industry and regulatory agencies have continuously worked to reduce the time for approval of a new pharmaceutical product, reduce the cost...