KET, unlike other hypnotic anesthetics, such as propofol, has little action on gamma-aminobutyric acid (GABA) receptors. Both KET and its metabolites are N-methyl d-Aspartate (NMDA) receptor antagonists. However, KET's pharmacological targets are not limited to this receptor. It was observed tha...
Although the liver is the main organ of drug metabolism, kidneys are also capable ofdrug biotransformation. For instance,mycophenolic acid,propofol, and 4-methylumbelliferone are metabolized to a greater extent by kidneys than by liver.89The kidneys contain cytochrome P450 isoenzymes in the epithe...
Despite the fact that alcohol abuse is the most common among anesthesiologists, the abuse of anesthetic agents causes more concern, due to its high dependence potential and consequences, which are often fatal. The most widely used drugs are opioids (fentanyl and sufentanil), propofol and inhalation...
Effect of sugammadex on QT/QTc interval prolongation when combined with QTc-prolonging sevoflurane or propofol anaesthesia. Clin Drug Investig. 2013;33:545–51. Article PubMed CAS Google Scholar De Kam P, Van Kuijk J, Prohn M, Thomsen T, Peeters P. Effects of sugammadex doses up to 32...
with supporting evidence from external databases Rank Drugbank ID Drug name Uniprot ID Target name Evidence 1 DB00653 2 DB00349 3 DB00818 4 DB01122 5 DB01239 6 DB00312 7 DB00829 8 DB00653 9 DB00740 10 DB00949 Magnesium sulfate Q01668 Clobazam P47870 Propofol Ambenonium Chlorprothixene ...
Frenkel pairs that survive the implantation remain until annealing. At elevated temperatures,T>∼600 °C, however, the mobility of the point defects is significant. During annealing, many of the interstitials and vacancies recombine either at the surface or in the bulk. The driving force of ...
In subsequent kinetic studies, CNF inhibited recombinant and human liver microsomal UGT1A9; Ki values ranged from 1.4 to 3.0 µM, depending on the substrate (propofol/4-methylumbelliferone) enzyme combination. Ki values for CNF inhibition of UGT1A1 were approximately 3-fold higher. Consistent ...
DISE was performed using propofol in patients considered to have upper respiratory tract obstruction as indicated by Muller’s maneuver. After completing the sleep endoscopy, the patient was intubated and surgery was performed (tonsillectomy and uvulopalatopharyngoplasty). A successful operation was ...
Drug classGeneric nameAvailabilityInteraction Baclofen Opioids Buprenorphine Codeine Fentanyl Idromorphone Morphine Methadone Nalbuphine Oxycodone Pentazocin Tramadole Medical prescription Co-administration could increase the sedative effect and the risk of a respiratory depression Anesthetic Propofol Medical prescript...
3.The method of claim 2 wherein the formula is based upon a linear interpolation of the maximum loading dose and the maximum maintenance rate recommend by the drug supplier. 4.The method of claim 3 wherein the drug is propofol and the formula is: ...