"Memantine has shown a significant and consistent benefit for moderate to severe Alzheimer's patients in multiple, well-controlled trials when used alone or in combination with a currently approved treatment. It is the first in a new class of Alzheimer's medications with a mechanism of action th...
fileticket=CHOZQPIof3U%3d&tabid=206&mid=1589)(requiredforalldrugsinclass)Namendawillbeapprovedonlyforpatientsmeetingbothofthefollowingcriteria:Diagnosisofdementia(ICD-9=290.xx,294.1,331.0)MiniMentalStateExam(MMSE)scoreof<15orequivalentNAMENDA(memantine)ANALGESICS/ANESTHETICS,TOPICALLIDODERM(lidocaine)...
Namenda; Agent for Alzheimer's Dementia Methotrexate Trexall; antimetabolite/antineoplastic Metoclopramide HCl Reglan; antiemetic Metolazone Zaroxolyn; diuretic Metoprolol Succinate Toprol-XL; antihypertensive Metoprolol Tartrate Lopressor; antihypertensive ...
Galantamine is in a class of drugs called cholinesterase inhibitors that also includes tacrine (Cognex), donezepil (Aricept), and rivastigmine (Exelon). Cholinesterase inhibitors inhibit (block) the action of acetylcholinesterase, the enzyme responsible for the destruction of acetylcholine. Acetylcholine ...
Therapy with this drug, which belongs to a class of medications called tumor necrosis factor (TNF)-alpha inhibitors, costs up to $2,784 per month. In 2010, Enbrel earned Amgen more than $3.3 billion in U.S. sales, or over 23% of the company's total revenue.1-5 Also Pfizer, which...
I think the second point here is the strength of evidence, which I already spoke to in my earlier comment, which is going to be important. So while the NCD is for a class, NCD did point that the data for every antibody will matter. And so, that's really I think where we think we...
Sensitivity analyses were conducted to test if there are differences in use by drug class or if beneficiaries with a diagnosis of dementia pre–Part D experienced an increase in use post–Part D. Results The No coverage group had a 38% increase in the odds ratio of any use of antidementia...
Depending upon plan design, market conditions, the extent to which manufacturer payments are shared with your plan and other factors as of the date of service, the preferred brand medication may or may not represent the lowest-cost brand medication within its class for you and/or your plan. ...
the same class, such as the nucleoside analogues, and include abacavir and lamivudine.14,16Other fixed-dose combinations, such as the HMG-CoA reductase inhibitor, atorvastatin, and the CCB, amlodipine, are used to treat hyperlipidemia and hypertension— 2 major risk factors for heart disease.14,...
The oldest and largest class of drugs for AD are cholinesterase inhibitors, which work to inhibit the action of acetylcholinesterase and/or butrylcholinesterase to increase the concentration of acetylcholine in synapses [96,97]. Tacrine was first synthesised in 1945 with the aim of creating an anti...