Hydroxychloroquine (HCQ) belongs to the class of 4-aminoquinolines. It is a hydroxylated version of?chloroquine with a similar mechanism of action but rather a safe profile. It is primarily an antimalarial drug but has been extensively used for treating rheumatoid arthritis, porphyria, discoid and...
These elements highlight the diversity of presentations of myocarditis depending on drug class, and show the emerging role of antineoplastic drugs in the field of drug-induced myocarditis.Similar content being viewed by others Real-world pharmacovigilance study of drug-induced autoimmune hepatitis from ...
Cumulative exposure to chloroquine and hydroxychloroquine determines the risk of toxicity. For hydroxychloroquine, this has been shown to be 1000 g, reached in 7 years with a daily dose of 400 mg, and for chloroquine, it is 460 g, reached in 5 years with a daily dose of 250 mg.51 For ...
Conclusion Remdesivir and baricitinib were approved for the treatment of hospitalized patients with severe COVID-19. Dexamethasone and methylprednisolone should be used with caution. Hydroxychloroquine, chloroquine, ivermectin, and azithromycin are ineffective for the treatment of the disease, and the ...
We also demonstrated that the drugs hydroxychloroquine (HQ; 10 μM), a known endosomal acidification inhibitor, as well as interferon (IFN)-β, IFN-α, and EIDD-2801 (molnupiravir), effectively blocked SARS-CoV-2 infection (Liu et al., 2020) (Figure S1C). Therefore, we used this ...
Also, Oubain, another inhibitor of clathrin-mediated, is being tested for its efficacy in drug trials for SARS-CoV-2 positive patients (Sisk et al. 2018). Recently, Chloroquine and its derivative hydroxychloroquine have garnered great interest as a therapy against SARS-CoV-2 infection (...
Hydroxychloroquine for autoimmune diseases. Rev. Med. Chil. 144, 232–240 (2016). Article PubMed Google Scholar Lai, Z. W. et al. Sirolimus in patients with clinically active systemic lupus erythematosus resistant to, or intolerant of, conventional medications: a single-arm, open-label, ...
The use of inhibitors of autophagy could therefore be a promising strategy for overcoming resistance. Hydroxychloroquine (HCQ) and proton pump inhibitors have been identified as inhibitors of autophagy because of their ability to block lysosomal acidification and autophago-some degradation (Marino et al...
there have been significant efforts in repurposing drugs approved for other diseases for COVID-19 treatment, some of which have been tested in clinical trials (e.g., dexamethasone [6], hydroxychloroquine and lopinavir/ritonavir [7]) and one ultimately approved by FDA for treatment of patients ho...
MTX is the most commonly used DMARD for JRA. Several DMARDs are also used to treat other rheumatic diseases (e.g., MTX in juvenile dermatomyositis [JDM], vasculitis, and uveitis; hydroxychloroquine in the management of SLE). In the treatment of arthritis, DMARDs are usually given in additio...